Skip to Main content Skip to Navigation
Theses

Modélisation de la dynamique des réseaux biologiques : applications en génétique et immunologie

Abstract : In this thesis, we focus on statistical modeling of biological data, and more particularly on the study of genetic and protein information.First, we have improved a statistical model of existing immunological data in mice, we have transposed it to human, in order to study the various recombinations that occur within the thymus, at the end of the embryonic life, between segments of genes from the portion V (D) J of the human chromosome 14, called recombinations V (D) J.Secondly, we studied the genetic information through genetic regulatory networks, for example in the case of a family illness called the "biliary atresia," as well as in the immune system control networks, which we have called "Immunetworks".In a last part, we propose a new approach for biological data compression, which includes a step of modeling the dynamic processes that gave rise to them: we call this approach the "Dynalet" transform and we apply it, among others, to NMR spectrometry signals, i.e., Nuclear Magnetic Resonance spectra of proteins and nucleic acids. This method consists in converting the peaks of the spectrometric signals into sounds, in order to construct an anharmonic instrument capable to reproduce periodized relaxation peaks from the NMR spectra of the 20 amino acids, as well as those of the 4 nucleic bases.
Document type :
Theses
Complete list of metadata

https://tel.archives-ouvertes.fr/tel-01560310
Contributor : ABES STAR :  Contact
Submitted on : Tuesday, July 11, 2017 - 2:45:06 PM
Last modification on : Friday, March 25, 2022 - 9:44:33 AM
Long-term archiving on: : Wednesday, January 24, 2018 - 10:40:22 PM

File

HAZGUI_2015_diffusion.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01560310, version 1

Collections

EPHE | UGA | CNRS | STAR | AGIM | PSL

Citation

Hana Hazgui. Modélisation de la dynamique des réseaux biologiques : applications en génétique et immunologie. Ingénierie biomédicale. Université Grenoble Alpes; Université de Sfax. Faculté des sciences, 2015. Français. ⟨NNT : 2015GREAS040⟩. ⟨tel-01560310⟩

Share

Metrics

Record views

337

Files downloads

113