E. L. Abel, J. M. Angel, K. Kiguchi, and J. Digiovanni, Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications, Nat Protoc, vol.4, pp.1350-1362, 2009.

Y. Achermann, T. Frauenfelder, S. Obrist, K. Zaugg, N. Corti et al., A rare but severe pulmonary side effect of cetuximab in two patients, BMJ Case Rep, 2012.

A. , X. Berditchevski, F. Odintsova, and E. , The effect of cell-ECM adhesion on signalling via the ErbB family of growth factor receptors, Biochem Soc Trans, vol.39, pp.568-573, 2011.

T. E. Angelini, E. Hannezo, X. Trepat, J. J. Fredberg, and D. A. Weitz, Cell migration driven by cooperative substrate deformation patterns, Phys Rev Lett, vol.104, p.168104, 2010.

H. E. Barker, T. R. Cox, and J. T. Erler, The rationale for targeting the LOX family in cancer, Nat Rev Cancer, vol.12, pp.540-552, 2012.

D. A. Beacham, M. D. Amatangelo, and E. Cukierman, Preparation of extracellular matrices produced by cultured and primary fibroblasts, Curr Protoc Cell Biol Chapter, vol.10, p.19, 2007.

F. Braig, M. Kriegs, M. Voigtlaender, B. Habel, T. Grob et al., Cetuximab Resistance in Head and Neck Cancer Is Mediated by EGFR-K521 Polymorphism, Cancer Res, vol.77, pp.1188-1199, 2017.

J. P. Brouland, P. Gelebart, T. Kovacs, J. Enouf, J. Grossmann et al., The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis, Am J Pathol, vol.167, pp.233-242, 2005.

F. Bruzzese, E. Di-gennaro, A. Avallone, S. Pepe, C. Arra et al., Synergistic antitumor activity of epidermal growth factor receptor tyrosine kinase inhibitor gefitinib and IFN-alpha in head and neck cancer cells in vitro and in vivo, Clin Cancer Res, vol.12, pp.617-625, 2006.

V. Casas-rua, P. Tomas-martin, A. M. Lopez-guerrero, I. S. Alvarez, E. Pozo-guisado et al., STIM1 phosphorylation triggered by epidermal growth factor mediates cell migration, Biochim Biophys Acta, vol.1853, pp.233-243, 2015.

Y. T. Chen, Y. F. Chen, W. T. Chiu, K. Y. Liu, Y. L. Liu et al.,

, Microtubule-associated histone deacetylase 6 supports the calcium store sensor STIM1 in mediating malignant cell behaviors, Cancer Res, vol.73, pp.4500-4509

G. Z. Cheng, S. Park, S. Shu, L. He, W. Kong et al., Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery, Curr Cancer Drug Targets, vol.8, pp.2-6, 2008.

F. Ciardiello and G. Tortora, Epidermal growth factor receptor (EGFR) as a target in cancer therapy: understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs, Eur J Cancer, vol.39, pp.1348-1354, 2003.

F. Ciardiello and G. Tortora, EGFR antagonists in cancer treatment, N Engl J Med, vol.358, pp.1160-1174, 2008.

C. Colpaert, P. Vermeulen, E. Van-marck, and L. Dirix, The presence of a fibrotic focus is an independent predictor of early metastasis in lymph node-negative breast cancer patients, Am J Surg Pathol, vol.25, pp.1557-1558, 2001.

S. Commandeur, V. Van-drongelen, F. R. De-gruijl, and A. Ghalbzouri, Epidermal growth factor receptor activation and inhibition in 3D in vitro models of normal skin and human cutaneous squamous cell carcinoma, Cancer Sci, vol.103, pp.2120-2126, 2012.

M. M. Cornwell, I. Pastan, and M. M. Gottesman, Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein, J Biol Chem, vol.262, pp.2166-2170, 1987.

F. M. Davis, I. Azimi, R. A. Faville, A. A. Peters, K. Jalink et al., Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent, Oncogene, vol.33, pp.2307-2316, 2014.

D. Maio, M. Gridelli, C. Normanno, N. Perrone, F. Ciardiello et al., Trying to compose the puzzle with all the pieces: epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer, J Cell Physiol, vol.205, pp.355-363, 2005.

C. Gaggioli, S. Hooper, C. Hidalgo-carcedo, R. Grosse, J. F. Marshall et al., , 2007.

, Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells, Nat Cell Biol, vol.9, pp.1392-1400

J. G. Goetz, S. Minguet, I. Navarro-lerida, J. J. Lazcano, R. Samaniego et al., Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis, Cell, vol.146, pp.148-163, 2011.

W. J. Gullick, Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers, Br Med Bull, vol.47, pp.87-98, 1991.

A. R. Hansen and L. L. Siu, Epidermal growth factor receptor targeting in head and neck cancer: have we been just skimming the surface?, J Clin Oncol, vol.31, pp.1381-1383, 2013.

S. Hooper, C. Gaggioli, and E. Sahai, A chemical biology screen reveals a role for Rab21-mediated control of actomyosin contractility in fibroblast-driven cancer invasion, Br J Cancer, vol.102, pp.392-402, 2010.

G. Jacquemet, H. Baghirov, M. Georgiadou, H. Sihto, E. Peuhu et al., L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling, Surg Neurol, vol.7, pp.275-283, 2001.

W. Jia, Z. Zhu, T. Zhang, G. Fan, P. Fan et al., Treatment of malignant ascites with a combination of chemotherapy drugs and intraperitoneal perfusion of verapamil, Cancer Chemother Pharmacol, vol.71, pp.1585-1590, 2013.

R. J. Leeman-neill, R. R. Seethala, S. V. Singh, M. L. Freilino, J. S. Bednash et al., Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma, Cancer Prev Res (Phila), vol.4, pp.230-237, 2011.

J. L. Leight, M. A. Wozniak, S. Chen, M. L. Lynch, C. et al., Matrix rigidity regulates a switch between TGF-beta1-induced apoptosis and epithelial-mesenchymal transition, Mol Biol Cell, vol.23, pp.781-791, 2012.

K. R. Levental, H. Yu, L. Kass, J. N. Lakins, M. Egeblad et al., Matrix crosslinking forces tumor progression by enhancing integrin signaling, Cell, vol.139, pp.891-906, 2009.

C. H. Lin, F. A. Pelissier, H. Zhang, J. Lakins, V. M. Weaver et al., , 2015.

, Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors, Mol Biol Cell, vol.26, pp.3946-3953

Y. Liu, Z. Lu, P. Fan, Q. Duan, Y. Li et al., Clinical efficacy of chemotherapy combined with verapamil in metastatic colorectal patients, Cell Biochem Biophys, vol.61, pp.393-398, 2011.

P. Lu, V. M. Weaver, and Z. Werb, The extracellular matrix: a dynamic niche in cancer progression, J Cell Biol, vol.196, pp.395-406, 2012.

J. L. Martiel, A. Leal, L. Kurzawa, M. Balland, I. Wang et al., Measurement of cell traction forces with ImageJ, Methods Cell Biol, vol.125, pp.269-287, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01142591

G. R. Monteith, N. Prevarskaya, and S. J. Roberts-thomson, The calcium-cancer signalling nexus, Nat Rev Cancer, vol.17, pp.367-380, 2017.

L. Moro, M. Venturino, C. Bozzo, L. Silengo, F. Altruda et al., , 1998.

, Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival

, EMBO J, vol.17, pp.6622-6632

A. Nabeshima, Y. Matsumoto, J. Fukushi, K. Iura, T. Matsunobu et al., Tumour-associated macrophages correlate with poor prognosis in myxoid liposarcoma and promote cell motility and invasion via the HB-EGF-EGFR-PI3K/Akt pathways, Br J Cancer, vol.112, pp.547-555, 2015.

S. Naito, S. Kotoh, T. Omoto, Y. Osada, K. Sagiyama et al., Prophylactic intravesical instillation chemotherapy against recurrence after a transurethral resection of superficial bladder cancer: a randomized controlled trial of doxorubicin plus verapamil versus doxorubicin alone, Cancer Chemother Pharmacol, vol.42, pp.367-372, 1998.

D. Nassar, M. Latil, B. Boeckx, D. Lambrechts, and C. Blanpain, Genomic landscape of carcinogeninduced and genetically induced mouse skin squamous cell carcinoma, Nat Med, vol.21, pp.946-954, 2015.

J. P. Neglia, S. C. Fitzsimmons, P. Maisonneuve, M. H. Schoni, F. Schoni-affolter et al., The risk of cancer among patients with cystic fibrosis. Cystic Fibrosis and Cancer Study Group, N Engl J Med, vol.332, pp.494-499, 1995.

Z. Ning, D. Chen, A. Liu, P. Fan, Q. Duan et al., , 2014.

D. M. Owens, S. Wei, and R. C. Smart, A multihit, multistage model of chemical carcinogenesis, Carcinogenesis, vol.20, pp.1837-1844, 1999.

M. J. Paszek, N. Zahir, K. R. Johnson, J. N. Lakins, G. I. Rozenberg et al., Tensional homeostasis and the malignant phenotype, Cancer Cell, vol.8, pp.241-254, 2005.

S. Pellegrin and H. Mellor, Rho GTPase activation assays, Curr Protoc Cell Biol Chapter, 2008.

C. Plutoni, E. Bazellieres, M. Le-borgne-rochet, F. Comunale, A. Brugues et al., P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces, J Cell Biol, vol.212, pp.199-217, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01878038

D. P. Allison, N. P. Mortensen, C. J. Sullivan, and M. J. Doktycz, Atomic force microscopy of biological samples, Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol, vol.2, pp.618-634, 2010.

C. Anderberg, H. Li, L. Fredriksson, J. Andrae, C. Betsholtz et al.,

, Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts, Cancer Res, vol.69, pp.369-378

C. D. Andl, T. Mizushima, H. Nakagawa, K. Oyama, H. Harada et al., Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo, J. Biol. Chem, vol.278, pp.1824-1830, 2003.

K. K. Ang, B. A. Berkey, X. Tu, H. Zhang, R. Katz et al., , 2002.

A. Argiris, M. V. Karamouzis, D. Raben, and R. L. Ferris, Head and neck cancer, Lancet Lond. Engl, vol.371, pp.1695-1709, 2008.

A. Arina, C. Idel, E. M. Hyjek, M. Alegre, Y. Wang et al., Tumor-associated fibroblasts predominantly come from local and not circulating precursors, Proc. Natl. Acad. Sci. U. S. A, vol.113, pp.7551-7556, 2016.

A. Arjonen, R. Kaukonen, and J. Ivaska, Filopodia and adhesion in cancer cell motility, Cell Adhes. Migr, vol.5, pp.421-430, 2011.

A. Arjonen, R. Kaukonen, E. Mattila, P. Rouhi, G. Högnäs et al., Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis, J. Clin. Invest, vol.124, pp.1069-1082, 2014.

C. R. Artalejo, M. E. Adams, and A. P. Fox, Three types of Ca2+ channel trigger secretion with different efficacies in chromaffin cells, Nature, vol.367, pp.72-76, 1994.

D. Aviezer, D. Hecht, M. Safran, M. Eisinger, G. David et al., Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis, Cell, vol.79, pp.1005-1013, 1994.

Y. H. Bae, K. L. Mui, B. Y. Hsu, S. Liu, A. Cretu et al., , 2014.

, A FAK-Cas-Rac-Lamellipodin Signaling Module Transduces Extracellular Matrix Stiffness into Mechanosensitive Cell Cycling, Sci Signal, vol.7, pp.57-57

A. Baker, D. Bird, G. Lang, T. R. Cox, and J. T. Erler, Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK, Oncogene, vol.32, pp.1863-1868, 2013.

C. H. Baker, D. Kedar, M. F. Mccarty, R. Tsan, K. L. Weber et al., Blockade of epidermal growth factor receptor signaling on tumor cells and tumor-associated endothelial cells for therapy of human carcinomas, Am. J. Pathol, vol.161, pp.929-938, 2002.

F. R. Balkwill, M. Capasso, and T. Hagemann, The tumor microenvironment at a glance, J Cell Sci, vol.125, pp.5591-5596, 2012.

M. Balsamo, F. Scordamaglia, G. Pietra, C. Manzini, C. Cantoni et al., Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity, Proc. Natl. Acad. Sci. U. S. A, vol.106, pp.20847-20852, 2009.

R. A. Bannister and K. G. Beam, CaV1.1: The atypical prototypical voltage-gated Ca2+ channel, Biochim. Biophys. Acta, vol.1828, pp.1587-1597, 2013.

S. Bao, G. Ouyang, X. Bai, Z. Huang, C. Ma et al., Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway, Cancer Cell, vol.5, pp.329-339, 2004.

X. Bao, B. Xie, Q. Li, X. Li, L. Wei et al., Nifedipine induced autophagy through Beclin1 and mTOR pathway in endometrial carcinoma cells, Chin. Med. J. (Engl.), vol.125, pp.3120-3126, 2012.

S. Barnes and M. E. Kelly, Calcium channels at the photoreceptor synapse, Adv. Exp. Med. Biol, vol.514, pp.465-476, 2002.

Y. Barrandon and H. Green, Cell migration is essential for sustained growth of keratinocyte colonies: the roles of transforming growth factor-alpha and epidermal growth factor, Cell, vol.50, pp.1131-1137, 1987.

V. Barry-hamilton, R. Spangler, D. Marshall, S. Mccauley, H. M. Rodriguez et al., Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment, Nat. Med, vol.16, pp.1009-1017, 2010.

M. Bartucci, R. Dattilo, C. Moriconi, A. Pagliuca, M. Mottolese et al., TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells, Oncogene, vol.34, pp.681-690, 2015.

J. Baselga, The EGFR as a target for anticancer therapy--focus on cetuximab, Eur. J. Cancer Oxf. Engl, vol.37, pp.16-22, 1990.

J. Baulida, M. H. Kraus, M. Alimandi, P. P. Di-fiore, and G. Carpenter, All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired, J. Biol. Chem, vol.271, pp.5251-5257, 1996.

J. Baum and H. S. Duffy, Fibroblasts and Myofibroblasts: What are we talking about?, J. Cardiovasc. Pharmacol, vol.57, pp.376-379, 2011.

B. P. Bean, M. Sturek, A. Puga, and K. Hermsmeyer, Calcium channels in muscle cells isolated from rat mesenteric arteries: modulation by dihydropyridine drugs, Circ. Res, vol.59, pp.229-235, 1986.

M. Bechem and H. Hoffmann, The molecular mode of action of the Ca agonist (-) BAY K 8644 on the cardiac Ca channel, Pflugers Arch, vol.424, pp.343-353, 1993.

N. T. Bech-hansen, M. J. Naylor, T. A. Maybaum, W. G. Pearce, B. Koop et al., Loss-of-function mutations in a calcium-channel alpha1-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness, Nat. Genet, vol.19, pp.264-267, 1998.

W. Bechtel, S. Mcgoohan, E. M. Zeisberg, G. A. Müller, H. Kalbacher et al., Methylation determines fibroblast activation and fibrogenesis in the kidney, Nat. Med, vol.16, pp.544-550, 2010.

D. Belpomme, S. Gauthier, E. Pujade-lauraine, T. Facchini, M. J. Goudier et al., Verapamil increases the survival of patients with anthracycline-resistant metastatic breast carcinoma, Ann. Oncol. Off. J. Eur. Soc. Med. Oncol, vol.11, pp.1471-1476, 2000.

C. Berasain, M. J. Perugorria, M. U. Latasa, J. Castillo, S. Goñi et al., The epidermal growth factor receptor: a link between inflammation and liver cancer, Exp. Biol. Med. Maywood NJ, vol.234, pp.713-725, 2009.

G. Bergers and L. E. Benjamin, Tumorigenesis and the angiogenic switch, Nat. Rev. Cancer, vol.3, pp.401-410, 2003.

G. J. Bergman, S. Khan, B. Danielsson, and N. Borg, Breast cancer risk and use of calcium channel blockers using Swedish population registries, JAMA Intern. Med, vol.174, pp.1700-1701, 2014.

S. Berjukow and S. Hering, Voltage-dependent acceleration of Ca(v)1.2 channel current decay by (+)-and (-)-isradipine, Br. J. Pharmacol, vol.133, pp.959-966, 2001.

M. J. Berridge, The AM and FM of calcium signalling, Nature, vol.386, pp.759-760, 1997.

M. J. Berridge, P. Lipp, and M. D. Bootman, The versatility and universality of calcium signalling, Nat. Rev. Mol. Cell Biol, vol.1, pp.11-21, 2000.

M. J. Berridge, M. D. Bootman, and H. L. Roderick, Calcium signalling: dynamics, homeostasis and remodelling, Nat. Rev. Mol. Cell Biol, vol.4, pp.517-529, 2003.

P. A. Berry, R. Birnie, A. P. Droop, N. J. Maitland, and A. T. Collins, The calcium sensor STIM1 is regulated by androgens in prostate stromal cells, The Prostate, vol.71, pp.1646-1655, 2011.

D. M. Bers, Cardiac excitation-contraction coupling, Nature, vol.415, pp.198-205, 2002.

M. Betson, E. Lozano, J. Zhang, and V. M. Braga, Rac activation upon cell-cell contact formation is dependent on signaling from the epidermal growth factor receptor, J. Biol. Chem, vol.277, pp.36962-36969, 2002.

N. Bhagavathula, K. C. Nerusu, G. J. Fisher, G. Liu, A. B. Thakur et al., Amphiregulin and epidermal hyperplasia: amphiregulin is required to maintain the psoriatic phenotype of human skin grafts on severe combined immunodeficient mice, Am. J. Pathol, vol.166, pp.1009-1016, 2005.

S. Bhat, D. T. Dao, C. E. Terrillion, M. Arad, R. J. Smith et al., , 2012.

, CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease, Prog. Neurobiol, vol.99, pp.1-14

N. A. Bhowmick, A. Chytil, D. Plieth, A. E. Gorska, N. Dumont et al., TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia, Science, vol.303, pp.848-851, 2004.

K. G. Birukov, Small GTPases in mechanosensitive regulation of endothelial barrier, Microvasc. Res, vol.77, pp.46-52, 2009.

J. S. Biscardi, M. C. Maa, D. A. Tice, M. E. Cox, T. H. Leu et al., c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function, J. Biol. Chem, vol.274, pp.8335-8343, 1999.

J. R. Bishop, M. Schuksz, and J. D. Esko, Heparan sulphate proteoglycans fine-tune mammalian physiology, Nature, vol.446, pp.1030-1037, 2007.

H. Bito, K. Deisseroth, and R. W. Tsien, CREB phosphorylation and dephosphorylation: a Ca(2+)-and stimulus duration-dependent switch for hippocampal gene expression, Cell, vol.87, pp.1203-1214, 1996.

M. P. Blaustein and W. J. Lederer, Sodium/calcium exchange: its physiological implications, Physiol. Rev, vol.79, pp.763-854, 1999.

B. A. Block, T. Imagawa, K. P. Campbell, and C. Franzini-armstrong, , 1988.

, J. Cell Biol, vol.107, pp.2587-2600

W. J. Blot, J. K. Mclaughlin, D. M. Winn, D. F. Austin, R. S. Greenberg et al., Smoking and drinking in relation to oral and pharyngeal cancer, Cancer Res, vol.48, pp.3282-3287, 1988.

B. Blouw, D. F. Seals, I. Pass, B. Diaz, and S. A. Courtneidge, A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo, Eur. J. Cell Biol, vol.87, pp.555-567, 2008.

L. Bochet, C. Lehuédé, S. Dauvillier, Y. Y. Wang, B. Dirat et al., Adipocyte-derived fibroblasts promote tumor progression and contribute to the desmoplastic reaction in breast cancer, Cancer Res, vol.73, pp.5657-5668, 2013.

S. Bonan, J. Albrengues, E. Grasset, S. Kuzet, N. Nottet et al., Membrane-bound ICAM-1 contributes to the onset of proinvasive tumor stroma by controlling acto-myosin contractility in carcinoma-associated fibroblasts, Oncotarget, vol.8, pp.1304-1320, 2016.

J. A. Bonner, P. M. Harari, J. Giralt, N. Azarnia, D. M. Shin et al., Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck, N. Engl. J. Med, vol.354, pp.567-578, 2006.

J. S. De-bono, H. I. Scher, R. B. Montgomery, C. Parker, M. C. Miller et al., Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.14, pp.6302-6309, 2008.

M. Borrell-pagès, F. Rojo, J. Albanell, J. Baselga, A. et al., TACE is required for the activation of the EGFR by TGF-alpha in tumors, EMBO J, vol.22, pp.1114-1124, 2003.

D. M. Boudreau, E. Koehler, S. J. Rulyak, S. Haneuse, R. Harrison et al., , 2008.

, Cardiovascular medication use and risk for colorectal cancer, Cancer Epidemiol. Biomark. Prev. Publ. Am. Assoc. Cancer Res. Cosponsored Am. Soc. Prev. Oncol, vol.17, pp.3076-3080

J. Brabender, K. D. Danenberg, R. Metzger, P. M. Schneider, J. Park et al., Epidermal growth factor receptor and HER2-neu mRNA expression in nonsmall cell lung cancer Is correlated with survival, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.7, pp.1850-1855, 2001.

B. Brachvogel, F. Pausch, P. Farlie, U. Gaipl, J. Etich et al., Isolated Anxa5+/Sca-1+ perivascular cells from mouse meningeal vasculature retain their perivascular phenotype in vitro and in vivo, Exp. Cell Res, vol.313, pp.2730-2743, 2007.

R. Brandt, R. Eisenbrandt, F. Leenders, W. Zschiesche, B. Binas et al.,

, Mammary gland specific hEGF receptor transgene expression induces neoplasia and inhibits differentiation, Oncogene, vol.19, pp.2129-2137

M. Braun, R. Ramracheya, P. R. Johnson, and P. Rorsman, Exocytotic properties of human pancreatic beta-cells, Ann. N. Y. Acad. Sci, vol.1152, pp.187-193, 2009.

W. N. Brennen, J. T. Isaacs, and S. R. Denmeade, Rationale Behind Targeting Fibroblast Activation Protein-Expressing Carcinoma-Associated Fibroblasts as a Novel Chemotherapeutic Strategy, Mol. Cancer Ther, vol.11, pp.257-266, 2012.

W. N. Brennen, D. M. Rosen, H. Wang, J. T. Isaacs, and S. R. Denmeade, Targeting carcinoma-associated fibroblasts within the tumor stroma with a fibroblast activation proteinactivated prodrug, J. Natl. Cancer Inst, vol.104, pp.1320-1334, 2012.

A. Brichkina, T. Bertero, H. M. Loh, N. T. Nguyen, A. Emelyanov et al., p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis, vol.30, pp.2623-2636, 2016.

B. Brodsky and A. V. Persikov, Molecular Structure of the Collagen Triple Helix, Adv. Protein Chem, vol.70, pp.301-339, 2005.

P. Bronsert, K. Enderle-ammour, M. Bader, S. Timme, M. Kuehs et al., Cancer cell invasion and EMT marker expression: a threedimensional study of the human cancer-host interface, J. Pathol, vol.234, pp.410-422, 2014.

P. C. Brooks, S. Strömblad, R. Klemke, D. Visscher, F. H. Sarkar et al., , 1995.

, Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin, J. Clin. Invest, vol.96, pp.1815-1822

C. J. Bruns, C. C. Solorzano, M. T. Harbison, S. Ozawa, R. Tsan et al., Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma, Cancer Res, vol.60, pp.2926-2935, 2000.

P. J. Buchanan and K. D. Mccloskey, CaV channels and cancer: canonical functions indicate benefits of repurposed drugs as cancer therapeutics, Eur. Biophys. J. EBJ, vol.45, pp.621-633, 2016.

M. Buchholz, A. Schatz, M. Wagner, P. Michl, T. Linhart et al., Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway, EMBO J, vol.25, pp.3714-3724, 2006.

A. W. Burgess, H. Cho, C. Eigenbrot, K. M. Ferguson, T. P. Garrett et al., An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors, Mol. Cell, vol.12, pp.541-552, 2003.

B. Burtness, M. A. Goldwasser, W. Flood, B. Mattar, A. A. Forastiere et al., Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.23, pp.8646-8654, 2005.

D. T. Butcher, T. Alliston, and V. M. Weaver, A tense situation: forcing tumour progression, Nat. Rev. Cancer, vol.9, pp.108-122, 2009.

J. M. Butler, H. Kobayashi, and S. Rafii, Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors, Nat. Rev. Cancer, vol.10, pp.138-146, 2010.

S. Cabodi, L. Moro, E. Bergatto, E. Boeri-erba, P. Di-stefano et al.,

, Integrin regulation of epidermal growth factor (EGF) receptor and of EGF-dependent responses, Biochem. Soc. Trans, vol.32, pp.438-442

D. Cai, S. Chen, M. Prasad, L. He, X. Wang et al., Mechanical feedback through E-cadherin promotes direction sensing during collective cell migration, Cell, vol.157, pp.1146-1159, 2014.

F. Calvo, N. Ege, A. Grande-garcia, S. Hooper, R. P. Jenkins et al., Mechanotransduction and YAPdependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts, Nat. Cell Biol, vol.15, pp.637-646, 2013.

, Comprehensive genomic characterization of head and neck squamous cell carcinomas, Cancer Genome Atlas Network, vol.517, pp.576-582, 2015.

B. Canguilhem, A. Pradines, C. Baudouin, C. Boby, I. Lajoie-mazenc et al., RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal growth factor receptor signaling, J. Biol. Chem, vol.280, pp.43257-43263, 2005.

E. Carafoli and T. Stauffer, The plasma membrane calcium pump: Functional domains, regulation of the activity, and tissue specificity of isoform expression, J. Neurobiol, vol.25, pp.312-324, 1994.

G. Carpenter, EGF receptor transactivation mediated by the proteolytic production of EGFlike agonists, Sci. STKE Signal Transduct. Knowl. Environ, p.1, 2000.

G. Carpenter, ErbB-4: mechanism of action and biology, Exp. Cell Res, vol.284, pp.66-77, 2003.

K. L. Carraway, J. L. Weber, M. J. Unger, J. Ledesma, N. Yu et al., , 1997.

, Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases, Nature, vol.387, pp.512-516

W. A. Catterall, Voltage-gated calcium channels, Cold Spring Harb. Perspect. Biol, vol.3, p.3947, 2011.

W. A. Catterall and T. M. Swanson, Structural Basis for Pharmacology of Voltage-Gated Sodium and Calcium Channels, Mol. Pharmacol, vol.88, pp.141-150, 2015.

J. Chambard, R. Lefloch, J. Pouysségur, and P. Lenormand, ERK implication in cell cycle regulation, Biochim. Biophys. Acta, vol.1773, pp.1299-1310, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00320768

A. F. Chambers, A. C. Groom, and I. C. Macdonald, Dissemination and growth of cancer cells in metastatic sites, Nat. Rev. Cancer, vol.2, pp.563-572, 2002.

C. E. Chan and D. J. Odde, Traction Dynamics of Filopodia on Compliant Substrates, Science, vol.322, pp.1687-1691, 2008.

C. S. Chan, J. N. Guzman, E. Ilijic, J. N. Mercer, C. Rick et al., Rejuvenation" protects neurons in mouse models of Parkinson's disease, Nature, vol.447, pp.1081-1086, 2007.

M. W. Chan, F. Chaudary, W. Lee, J. W. Copeland, and C. A. Mcculloch, Force-induced Myofibroblast Differentiation through Collagen Receptors Is Dependent on Mammalian Diaphanous (mDia), J. Biol. Chem, vol.285, pp.9273-9281, 2010.

F. Chang, J. T. Lee, P. M. Navolanic, L. S. Steelman, J. G. Shelton et al., Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy, Leukemia, vol.17, pp.590-603, 2003.

H. Chang, D. J. Riese, W. Gilbert, D. F. Stern, and U. J. Mcmahan, Ligands for ErbB-family receptors encoded by a neuregulin-like gene, Nature, vol.387, pp.509-512, 1997.

A. Chattopadhyay, M. Vecchi, Q. Ji, R. Mernaugh, and G. Carpenter, The role of individual SH2 domains in mediating association of phospholipase C-gamma1 with the activated EGF receptor, J. Biol. Chem, vol.274, pp.26091-26097, 1999.

J. Chen, Y. Yao, C. Gong, F. Yu, S. Su et al., , 2011.

Q. Chen, Q. Zhang, F. Zhong, S. Guo, Z. Jin et al., Association between calcium channel blockers and breast cancer: a meta-analysis of observational studies, Pharmacoepidemiol. Drug Saf, vol.23, pp.711-718, 2014.

R. Chen, X. Zeng, R. Zhang, J. Huang, X. Kuang et al.,

X. Chen, O. Nadiarynkh, S. Plotnikov, and P. J. Campagnola, Second harmonic generation microscopy for quantitative analysis of collagen fibrillar structure, Nat. Protoc, vol.7, pp.654-669, 2012.

Y. Chen, W. Chiu, Y. Chen, P. Lin, H. Huang et al., Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis, Proc. Natl. Acad. Sci. U. S. A, vol.108, pp.15225-15230, 2011.

H. Cheng, Z. Zhang, R. Rodriguez-barrueco, A. Borczuk, H. Liu et al., Functional genomics screen identifies YAP1 as a key determinant to enhance treatment sensitivity in lung cancer cells, Oncotarget, vol.7, pp.28976-28988, 2015.

J. Cheng, H. Huang, Z. Zhang, E. Shapiro, A. Pellicer et al., , 2002.

, Overexpression of epidermal growth factor receptor in urothelium elicits urothelial hyperplasia and promotes bladder tumor growth, Cancer Res, vol.62, pp.4157-4163

X. Cheng, J. Pachuau, E. Blaskova, M. Asuncion-chin, J. Liu et al., Am. J. Physiol. Heart Circ. Physiol, vol.297, pp.680-688, 2009.

B. S. Cherpelis, C. Marcusen, and P. G. Lang, Prognostic factors for metastasis in squamous cell carcinoma of the skin, Dermatol. Surg. Off. Publ. Am. Soc. Dermatol. Surg. Al, vol.28, pp.268-273, 2002.

K. J. Cheung, E. Gabrielson, Z. Werb, and A. J. Ewald, Collective invasion in breast cancer requires a conserved basal epithelial program, Cell, vol.155, pp.1639-1651, 2013.

K. J. Cheung, V. Padmanaban, V. Silvestri, K. Schipper, J. D. Cohen et al., Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters, Proc. Natl. Acad. Sci. U. S. A, vol.113, pp.854-863, 2016.

A. C. Chiang and J. Massagué, Molecular Basis of Metastasis, N. Engl. J. Med, vol.359, pp.2814-2823, 2008.

W. Chiou, Effect of Abeta exposure on the mRNA expression patterns of voltage-sensitive calcium channel alpha 1 subunits (alpha 1A-alpha 1D) in human SK-N-SH neuroblastoma, Neurochem. Int, vol.49, pp.256-261, 2006.

H. Cho and D. J. Leahy, Structure of the extracellular region of HER3 reveals an interdomain tether, Science, vol.297, pp.1330-1333, 2002.

H. Cho, K. Mason, K. X. Ramyar, A. M. Stanley, S. B. Gabelli et al., Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab, Nature, vol.421, pp.756-760, 2003.

C. R. Chong and P. A. Jänne, The quest to overcome resistance to EGFR-targeted therapies in cancer, Nat. Med, vol.19, pp.1389-1400, 2013.

F. Ciardiello, Epidermal growth factor receptor tyrosine kinase inhibitors as anticancer agents, Drugs, vol.60, issue.1, pp.41-42, 2000.

F. Ciardiello, N. Kim, M. L. Mcgeady, D. S. Liscia, T. Saeki et al., Expression of transforming growth factor alpha (TGF alpha) in breast cancer, Ann. Oncol. Off. J. Eur. Soc. Med. Oncol, vol.2, pp.169-182, 1991.

P. Cirri and P. Chiarugi, Cancer associated fibroblasts: the dark side of the coin, Am. J. Cancer Res, vol.1, pp.482-497, 2011.

P. Cirri and P. Chiarugi, Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression, Cancer Metastasis Rev, vol.31, pp.195-208, 2012.

A. Citri, K. B. Skaria, Y. , and Y. , The deaf and the dumb: the biology of ErbB-2 and ErbB-3, 2003.

, Exp. Cell Res, vol.284, pp.54-65

D. E. Clapham, Calcium signaling, Cell, vol.80, pp.259-268, 1995.

D. E. Clapham, L. W. Runnels, and C. Strübing, The TRP ion channel family, Nat. Rev. Neurosci, vol.2, pp.387-396, 2001.

A. G. Clark and D. M. Vignjevic, Modes of cancer cell invasion and the role of the microenvironment, Curr. Opin. Cell Biol, vol.36, pp.13-22, 2015.

E. A. Clark, W. G. King, J. S. Brugge, M. Symons, and R. O. Hynes, Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases, J. Cell Biol, vol.142, pp.573-586, 1998.

E. S. Clark, B. Brown, A. S. Whigham, A. Kochaishvili, W. G. Yarbrough et al., Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon, Oncogene, vol.28, pp.431-444, 2009.

R. J. Coffey, R. Derynck, J. N. Wilcox, T. S. Bringman, A. S. Goustin et al.,

, Production and auto-induction of transforming growth factor-alpha in human keratinocytes, Nature, vol.328, pp.817-820

S. J. Cohen, C. J. Punt, N. Iannotti, B. H. Saidman, K. D. Sabbath et al., Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.26, pp.3213-3221, 2008.

K. Collins, T. Jacks, and N. P. Pavletich, The cell cycle and cancer, Proc. Natl. Acad. Sci. U. S. A, vol.94, pp.2776-2778, 1997.

J. Condeelis and J. W. Pollard, Macrophages: obligate partners for tumor cell migration, invasion, and metastasis, Cell, vol.124, pp.263-266, 2006.

M. W. Conklin, J. C. Eickhoff, K. M. Riching, C. A. Pehlke, K. W. Eliceiri et al., Aligned collagen is a prognostic signature for survival in human breast carcinoma, Am. J. Pathol, vol.178, pp.1221-1232, 2011.

P. W. Cook, P. A. Mattox, W. W. Keeble, M. R. Pittelkow, G. D. Plowman et al., A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin, Mol. Cell. Biol, vol.11, pp.2547-2557, 1991.

P. W. Cook, M. R. Pittelkow, W. W. Keeble, R. Graves-deal, R. J. Coffey et al., , 1992.

, Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas, Cancer Res, vol.52, pp.3224-3227

P. W. Cook, M. Piepkorn, C. H. Clegg, G. D. Plowman, J. M. Demay et al.,

, Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype, J. Clin. Invest, vol.100, pp.2286-2294

P. W. Cook, J. R. Brown, K. A. Cornell, and M. R. Pittelkow, Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis, Exp. Dermatol, vol.13, pp.347-356, 2004.

M. Cordenonsi, F. Zanconato, L. Azzolin, M. Forcato, A. Rosato et al., The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on, Breast Cancer Cells. Cell, vol.147, pp.759-772, 2011.

A. L. Correia and M. J. Bissell, The tumor microenvironment is a dominant force in multidrug resistance, Drug Resist. Updat. Rev. Comment. Antimicrob. Anticancer Chemother, vol.15, pp.39-49, 2012.

D. B. Costa, B. Halmos, A. Kumar, S. T. Schumer, M. S. Huberman et al., BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations, PLoS Med, vol.4, pp.1669-1679, 2007.

B. Costa-silva, N. M. Aiello, A. J. Ocean, S. Singh, H. Zhang et al., Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver, Nat. Cell Biol, vol.17, pp.816-826, 2015.

D. E. Costea, A. Hills, A. H. Osman, J. Thurlow, G. Kalna et al., Identification of two distinct carcinoma-associated fibroblast subtypes with differential tumor-promoting abilities in oral squamous cell carcinoma, Cancer Res, vol.73, pp.3888-3901, 2013.

L. M. Coussens, B. Fingleton, and L. M. Matrisian, Matrix metalloproteinase inhibitors and cancer: trials and tribulations, Science, vol.295, pp.2387-2392, 2002.

T. R. Cox and J. T. Erler, Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer, Dis. Model. Mech, vol.4, pp.165-178, 2011.

E. A. Cox, S. K. Sastry, and A. Huttenlocher, Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases, Mol. Biol. Cell, vol.12, pp.265-277, 2001.

T. R. Cox, D. Bird, A. Baker, H. E. Barker, M. W. Ho et al., LOXmediated collagen crosslinking is responsible for fibrosis-enhanced metastasis, Cancer Res, vol.73, pp.1721-1732, 2013.

M. S. Cragg, J. Kuroda, H. Puthalakath, D. C. Huang, and A. Strasser, Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics, PLoS Med, vol.4, pp.1681-1689, 2007.

Y. Crawford, I. Kasman, L. Yu, C. Zhong, X. Wu et al., , 2009.

, PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment, Cancer Cell, vol.15, pp.21-34

M. Crisan, S. Yap, L. Casteilla, C. Chen, M. Corselli et al., A perivascular origin for mesenchymal stem cells in multiple human organs, Cell Stem Cell, vol.3, pp.301-313, 2008.

M. Cristofanilli, G. T. Budd, M. J. Ellis, A. Stopeck, J. Matera et al., Circulating tumor cells, disease progression, and survival in metastatic breast cancer, N. Engl. J. Med, vol.351, pp.781-791, 2004.

H. Cui, C. Freeman, G. A. Jacobson, and D. H. Small, Proteoglycans in the central nervous system: role in development, neural repair, and Alzheimer's disease, IUBMB Life, vol.65, pp.108-120, 2013.

B. M. Curtis and W. A. Catterall, Phosphorylation of the calcium antagonist receptor of the voltage-sensitive calcium channel by cAMP-dependent protein kinase, Proc. Natl. Acad. Sci. U. S. A, vol.82, pp.2528-2532, 1985.

B. M. Curtis and W. A. Catterall, Reconstitution of the voltage-sensitive calcium channel purified from skeletal muscle transverse tubules, Biochemistry (Mosc.), vol.25, pp.3077-3083, 1986.

B. Dabovic, Y. Chen, J. Choi, E. C. Davis, L. Y. Sakai et al., Control of Lung Development by Latent TGF-? Binding Proteins, J. Cell. Physiol, vol.226, pp.1499-1509, 2011.

K. N. Dahl, A. J. Ribeiro, and J. Lammerding, Nuclear shape, mechanics, and mechanotransduction, Circ. Res, vol.102, pp.1307-1318, 2008.

A. J. Daly, L. Mcilreavey, and C. R. Irwin, Regulation of HGF and SDF-1 expression by oral fibroblasts--implications for invasion of oral cancer, Oral Oncol, vol.44, pp.646-651, 2008.

J. S. Damiano, A. E. Cress, L. A. Hazlehurst, A. A. Shtil, and W. S. Dalton, Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines, Blood, vol.93, pp.1658-1667, 1999.

T. E. Danciu, R. M. Adam, K. Naruse, M. R. Freeman, and P. V. Hauschka, Calcium regulates the PI3K-Akt pathway in stretched osteoblasts, FEBS Lett, vol.536, pp.193-197, 2003.

I. Darby, O. Skalli, and G. Gabbiani, Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing, Lab. Investig. J. Tech. Methods Pathol, vol.63, pp.21-29, 1990.

H. Daub, F. U. Weiss, C. Wallasch, and A. Ullrich, Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors, Nature, vol.379, pp.557-560, 1996.

A. Davies, J. Hendrich, A. T. Van-minh, J. Wratten, L. Douglas et al., Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels, Trends Pharmacol. Sci, vol.28, pp.220-228, 2007.

F. M. Davis, P. A. Kenny, E. T. Soo, .. Van-denderen, B. J. Thompson et al., Remodeling of purinergic receptor-mediated Ca2+ signaling as a consequence of EGF-induced epithelial-mesenchymal transition in breast cancer cells, PloS One, vol.6, 2011.

F. M. Davis, A. A. Peters, D. M. Grice, P. J. Cabot, M. Parat et al., Non-stimulated, agonist-stimulated and store-operated Ca2+ influx in MDA-MB-468 breast cancer cells and the effect of EGF-induced EMT on calcium entry, PloS One, vol.7, p.36923, 2012.

F. M. Davis, I. Azimi, R. A. Faville, A. A. Peters, K. Jalink et al., Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent, Oncogene, vol.33, pp.2307-2316, 2014.

S. J. Davis, K. E. Sheppard, M. S. Anglesio, J. George, N. Traficante et al., Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition, Mol. Cancer Ther, vol.14, pp.1495-1503, 2015.

R. De-bont and N. Van-larebeke, Endogenous DNA damage in humans: a review of quantitative data, Mutagenesis, vol.19, pp.169-185, 2004.

K. S. De-jongh, B. J. Murphy, A. A. Colvin, J. W. Hell, M. Takahashi et al., adenosine 3',5'-cyclic monophosphate-dependent protein kinase, Biochemistry (Mosc.), vol.35, pp.10392-10402, 1996.

D. De-stefani, R. Rizzuto, and T. Pozzan, Enjoy the Trip: Calcium in Mitochondria Back and Forth, Annu. Rev. Biochem, vol.85, pp.161-192, 2016.

D. Wever, O. Nguyen, Q. Van-hoorde, L. Bracke, M. Bruyneel et al.,

-. Tenascin and S. F. Hgf, produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, vol.18, pp.1016-1018

D. Wever, O. Demetter, P. Mareel, M. Bracke, and M. , Stromal myofibroblasts are drivers of invasive cancer growth, Int. J. Cancer, vol.123, pp.2229-2238, 2008.

D. Wever, O. Van-bockstal, M. Mareel, M. Hendrix, A. Bracke et al., Carcinomaassociated fibroblasts provide operational flexibility in metastasis, Semin. Cancer Biol, vol.25, pp.33-46, 2014.

J. D. Debes, R. O. Roberts, D. J. Jacobson, C. J. Girman, M. M. Lieber et al., Inverse association between prostate cancer and the use of calcium channel blockers, Cancer Epidemiol. Biomark. Prev. Publ. Am. Assoc. Cancer Res. Cosponsored Am. Soc. Prev. Oncol, vol.13, pp.255-259, 2004.

M. A. Dechantsreiter, E. Planker, B. Mathä, E. Lohof, G. Hölzemann et al., N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists, J. Med. Chem, vol.42, pp.3033-3040, 1999.

K. Deisseroth, E. K. Heist, and R. W. Tsien, Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons, Nature, vol.392, pp.198-202, 1998.

C. Delbaldo, E. Raymond, K. Vera, L. Hammershaimb, K. Kaucic et al., Phase I and pharmacokinetic study of etaracizumab (Abegrin), a humanized monoclonal antibody against alphavbeta3 integrin receptor, in patients with advanced solid tumors, Invest. New Drugs, vol.26, pp.35-43, 2008.

D. G. Denardo, D. J. Brennan, E. Rexhepaj, B. Ruffell, S. L. Shiao et al., Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy, Cancer Discov, vol.1, pp.54-67, 2011.

H. Denys, G. Braems, K. Lambein, P. Pauwels, A. Hendrix et al., The extracellular matrix regulates cancer progression and therapy response: implications for prognosis and treatment, Curr. Pharm. Des, vol.15, pp.1373-1384, 2009.

J. S. Desgrosellier and D. A. Cheresh, Integrins in cancer: biological implications and therapeutic opportunities, Nat. Rev. Cancer, vol.10, pp.9-22, 2010.

A. Desmoulière, M. Redard, I. Darby, and G. Gabbiani, Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar, Am. J. Pathol, vol.146, pp.56-66, 1995.

A. Desmoulière, C. Guyot, and G. Gabbiani, The stroma reaction myofibroblast: a key player in the control of tumor cell behavior, Int. J. Dev. Biol, vol.48, pp.509-517, 2004.

A. Desmoulière, C. Chaponnier, and G. Gabbiani, Tissue repair, contraction, and the myofibroblast, Wound Repair Regen. Off. Publ. Wound Heal. Soc. Eur. Tissue Repair Soc, vol.13, pp.7-12, 2005.

E. E. Devore, S. Kim, C. A. Ramin, L. R. Wegrzyn, J. Massa et al., Antihypertensive medication use and incident breast cancer in women, Breast Cancer Res. Treat, vol.150, pp.219-229, 2015.

L. Devy and D. T. Dransfield, New Strategies for the Next Generation of Matrix-Metalloproteinase Inhibitors: Selectively Targeting Membrane-Anchored MMPs with Therapeutic Antibodies, Biochem. Res. Int, 2011.

D. Fiore, P. P. Pierce, J. H. Kraus, M. H. Segatto, O. King et al., erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells, Science, vol.237, pp.178-182, 1987.

D. Fiore, P. P. Pierce, J. H. Fleming, T. P. Hazan, R. Ullrich et al., Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells, Cell, vol.51, pp.1063-1070, 1987.

D. Marco, E. Pierce, J. H. Fleming, T. P. Kraus, M. H. Molloy et al.,

, Autocrine interaction between TGF alpha and the EGF-receptor: quantitative requirements for induction of the malignant phenotype, Oncogene, vol.4, pp.831-838

L. A. Diaz, R. T. Williams, J. Wu, I. Kinde, J. R. Hecht et al., The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers, Nature, vol.486, pp.537-540, 2012.

J. Díaz-martín, M. Á. López-garcía, L. Romero-pérez, M. R. Atienza-amores, M. L. Pecero et al., Nuclear TAZ expression associates with the triple-negative phenotype in breast cancer, Endocr. Relat. Cancer, vol.22, pp.443-454, 2015.

M. T. Dimanche-boitrel, L. Vakaet, P. Pujuguet, B. Chauffert, M. S. Martin et al., In vivo and in vitro invasiveness of a rat colon-cancer cell line maintaining E-cadherin expression: an enhancing role of tumor-associated myofibroblasts, Int. J. Cancer, vol.56, pp.512-521, 1994.

H. Ding, P. Shannon, N. Lau, X. Wu, L. Roncari et al., Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model, Cancer Res, vol.63, pp.1106-1113, 2003.

B. Dirat, L. Bochet, M. Dabek, D. Daviaud, S. Dauvillier et al., Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion, Cancer Res, vol.71, pp.2455-2465, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00819288

N. C. Direkze, A. , and M. R. , Bone marrow and tumour stroma: an intimate relationship, Hematol. Oncol, vol.24, pp.189-195, 2006.

N. C. Direkze, K. Hodivala-dilke, R. Jeffery, T. Hunt, R. Poulsom et al., Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts, Cancer Res, vol.64, pp.8492-8495, 2004.

N. T. Doan, E. S. Paulsen, P. Sehgal, J. V. Møller, P. Nissen et al., Targeting thapsigargin towards tumors, vol.97, pp.2-7, 2015.

D. S. Dolberg, R. Hollingsworth, M. Hertle, and M. J. Bissell, Wounding and its role in RSVmediated tumor formation, Science, vol.230, pp.676-678, 1985.

R. E. Dolmetsch, R. S. Lewis, C. C. Goodnow, and J. I. Healy, Differential activation of transcription factors induced by Ca2+ response amplitude and duration, Nature, vol.386, pp.855-858, 1997.

R. E. Dolmetsch, U. Pajvani, K. Fife, J. M. Spotts, and M. E. Greenberg, Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway, Science, vol.294, pp.333-339, 2001.

A. C. Dolphin, Beta subunits of voltage-gated calcium channels, J. Bioenerg. Biomembr, vol.35, pp.599-620, 2003.

A. M. Dominey, X. J. Wang, L. E. King, L. B. Nanney, T. A. Gagne et al., Targeted overexpression of transforming growth factor alpha in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous, squamous papillomas, Cell Growth Differ. Mol. Biol. J. Am. Assoc. Cancer Res, vol.4, pp.1071-1082, 1993.

J. Downward, Y. Yarden, E. Mayes, G. Scrace, N. Totty et al., Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences, Nature, vol.307, pp.521-527, 1984.

S. Dragoni, U. Laforenza, E. Bonetti, F. Lodola, C. Bottino et al., Vascular endothelial growth factor stimulates endothelial colony forming cells proliferation and tubulogenesis by inducing oscillations in intracellular Ca2+ concentration, Stem Cells Dayt. Ohio, vol.29, pp.1898-1907, 2011.

G. D'souza, A. R. Kreimer, R. Viscidi, M. Pawlita, C. Fakhry et al., Case-control study of human papillomavirus and oropharyngeal cancer, N. Engl. J. Med, vol.356, pp.1944-1956, 2007.

D. G. Duda, A. M. Duyverman, M. Kohno, M. Snuderl, E. J. Steller et al., Malignant cells facilitate lung metastasis by bringing their own soil, Proc. Natl. Acad. Sci. U. S. A, vol.107, pp.21677-21682, 2010.

S. Dupont, L. Morsut, M. Aragona, E. Enzo, S. Giulitti et al., Role of YAP/TAZ in mechanotransduction, Nature, vol.474, pp.179-183, 2011.

H. F. Dvorak, Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing, N. Engl. J. Med, vol.315, pp.1650-1659, 1986.

M. Egeblad, E. S. Nakasone, and Z. Werb, Tumors as Organs: Complex Tissues that Interface with the Entire Organism, Dev. Cell, vol.18, pp.884-901, 2010.

,. El-azreq, D. Naci, A. , and F. , Collagen/?1 integrin signaling up-regulates the ABCC1/MRP-1 transporter in an ERK/MAPK-dependent manner, Mol. Biol. Cell, vol.23, pp.3473-3484, 2012.

J. T. Elder, G. J. Fisher, P. B. Lindquist, G. L. Bennett, M. R. Pittelkow et al., Overexpression of transforming growth factor alpha in psoriatic epidermis, Science, vol.243, pp.811-814, 1989.

K. Elenius, C. J. Choi, S. Paul, E. Santiestevan, E. Nishi et al., Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase, Oncogene, vol.18, pp.2607-2615, 1999.

L. Eliasson, F. Abdulkader, M. Braun, J. Galvanovskis, M. B. Hoppa et al., Novel aspects of the molecular mechanisms controlling insulin secretion, J. Physiol, vol.586, pp.3313-3324, 2008.

M. El-sibai and J. M. Backer, Phospholipase C gamma negatively regulates Rac/Cdc42 activation in antigen-stimulated mast cells, Eur. J. Immunol, vol.37, pp.261-270, 2007.

J. A. Engelman, K. Zejnullahu, T. Mitsudomi, Y. Song, C. Hyland et al., MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling, Science, vol.316, pp.1039-1043, 2007.

J. T. Erler, K. L. Bennewith, T. R. Cox, G. Lang, D. Bird et al., , 2009.

, Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche, Cancer Cell, vol.15, pp.35-44

E. A. Ertel, K. P. Campbell, M. M. Harpold, F. Hofmann, Y. Mori et al., Nomenclature of voltage-gated calcium channels, Neuron, vol.25, pp.533-535, 2000.

J. D. Esko, K. Kimata, U. Lindahl, R. D. Varki, J. D. Cummings et al., Proteoglycans and Sulfated Glycosaminoglycans, Essentials of Glycobiology, 2009.

A. J. Ewald, A. Brenot, M. Duong, B. S. Chan, and Z. Werb, Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis, Dev. Cell, vol.14, pp.570-581, 2008.

K. B. Ewan, G. Shyamala, S. A. Ravani, Y. Tang, R. Akhurst et al., Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation, Am. J. Pathol, vol.160, pp.2081-2093, 2002.

A. Fabiato, Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum, Am. J. Physiol, vol.245, pp.1-14, 1983.

M. Faehling, J. Kroll, K. J. Föhr, G. Fellbrich, U. Mayr et al., , 2002.

, Essential role of calcium in vascular endothelial growth factor A-induced signaling: mechanism of the antiangiogenic effect of carboxyamidotriazole, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, vol.16, pp.1805-1807

M. Faouzi, F. Hague, M. Potier, A. Ahidouch, H. Sevestre et al., Downregulation of Orai3 arrests cell-cycle progression and induces apoptosis in breast cancer cells but not in normal breast epithelial cells, J. Cell. Physiol, vol.226, pp.542-551, 2011.

M. Faouzi, P. Kischel, F. Hague, A. Ahidouch, N. Benzerdjeb et al., ORAI3 silencing alters cell proliferation and cell cycle progression via c-myc pathway in breast cancer cells, Biochim. Biophys. Acta, vol.1833, pp.752-760, 2013.

P. Fedi, J. H. Pierce, P. P. Di-fiore, and M. H. Kraus, Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members, Mol. Cell. Biol, vol.14, pp.492-500, 1994.

J. Feng, J. Gou, J. Jia, T. Yi, T. Cui et al., Verteporfin, a suppressor of YAP-TEAD complex, presents promising antitumor properties on ovarian cancer, OncoTargets Ther, vol.9, pp.5371-5381, 2016.

M. Flourakis, V. Lehen'kyi, B. Beck, M. Raphaël, M. Vandenberghe et al., Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells, Cell Death Dis, issue.1, p.75, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00520275

C. Frantz, K. M. Stewart, and V. M. Weaver, The extracellular matrix at a glance, J. Cell Sci, vol.123, pp.4195-4200, 2010.

P. Fratzl, K. Misof, I. Zizak, G. Rapp, H. Amenitsch et al., Fibrillar Structure and Mechanical Properties of Collagen, J. Struct. Biol, vol.122, pp.119-122, 1998.

A. R. French, D. K. Tadaki, S. K. Niyogi, and D. A. Lauffenburger, Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction, J. Biol. Chem, vol.270, pp.4334-4340, 1995.

P. Friedl and D. Gilmour, Collective cell migration in morphogenesis, regeneration and cancer, Nat. Rev. Mol. Cell Biol, vol.10, pp.445-457, 2009.

P. Friedl and K. Wolf, Tumour-cell invasion and migration: diversity and escape mechanisms, Nat. Rev. Cancer, vol.3, pp.362-374, 2003.

P. Friedl and K. Wolf, Tube travel: the role of proteases in individual and collective cancer cell invasion, Cancer Res, vol.68, pp.7247-7249, 2008.

P. Friedl and K. Wolf, Plasticity of cell migration: a multiscale tuning model, J. Cell Biol, vol.188, pp.11-19, 2010.

J. C. Friedland, M. H. Lee, and D. Boettiger, Mechanically activated integrin switch controls alpha5beta1 function, Science, vol.323, pp.642-644, 2009.

S. M. Frisch, K. Vuori, E. Ruoslahti, C. , and P. Y. , Control of adhesion-dependent cell survival by focal adhesion kinase, J. Cell Biol, vol.134, pp.793-799, 1996.

F. E. Froeling, C. Feig, C. Chelala, R. Dobson, C. E. Mein et al., Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-?-catenin signaling to slow tumor progression, Gastroenterology, vol.141, pp.1-14, 1497.

D. Fukumura, R. Xavier, T. Sugiura, Y. Chen, E. C. Park et al., Tumor induction of VEGF promoter activity in stromal cells, Cell, vol.94, pp.715-725, 1998.

A. Fullár, J. Dudás, L. Oláh, P. Hollósi, Z. Papp et al., Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression, BMC Cancer, vol.15, p.256, 2015.

G. Gabbiani, G. B. Ryan, and G. Majne, Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction, Experientia, vol.27, pp.549-550, 1971.

C. Gaggioli, S. Hooper, C. Hidalgo-carcedo, R. Grosse, J. F. Marshall et al.,

, Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells, Nat. Cell Biol, vol.9, pp.1392-1400

T. Gao, A. E. Cuadra, H. Ma, M. Bunemann, B. L. Gerhardstein et al., C-terminal fragments of the alpha 1C (CaV1.2) subunit associate with and regulate Ltype calcium channels containing C-terminal-truncated alpha 1C subunits, J. Biol. Chem, vol.276, pp.21089-21097, 2001.

T. P. Garrett, N. M. Mckern, M. Lou, T. C. Elleman, T. E. Adams et al., The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors, Mol. Cell, vol.11, pp.495-505, 2003.

P. Gascard and T. D. Tlsty, Carcinoma-associated fibroblasts: orchestrating the composition of malignancy, Genes Dev, vol.30, pp.1002-1019, 2016.

M. Gassmann, F. Casagranda, D. Orioli, H. Simon, C. Lai et al., Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor, Nature, vol.378, pp.390-394, 1995.

R. Ge, Y. Tai, Y. Sun, K. Zhou, S. Yang et al., Critical role of TRPC6 channels in VEGF-mediated angiogenesis, Cancer Lett, vol.283, pp.43-51, 2009.

M. Gees, B. Colsoul, and B. Nilius, The role of transient receptor potential cation channels in Ca2+ signaling, Cold Spring Harb. Perspect. Biol, vol.2, p.3962, 2010.

B. L. Gerhardstein, T. Gao, M. Bünemann, T. S. Puri, A. Adair et al., , 2000.

, Proteolytic processing of the C terminus of the alpha(1C) subunit of L-type calcium channels and the role of a proline-rich domain in membrane tethering of proteolytic fragments, J. Biol. Chem, vol.275, pp.8556-8563

L. E. Gerweck and K. Seetharaman, Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer, Cancer Res, vol.56, pp.1194-1198, 1996.

C. Gialeli, A. D. Theocharis, and N. K. Karamanos, Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting, FEBS J, vol.278, pp.16-27, 2011.

E. Giannoni, F. Bianchini, L. Masieri, S. Serni, E. Torre et al., Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelialmesenchymal transition and cancer stemness, Cancer Res, vol.70, pp.6945-6956, 2010.

J. Gillis, E. Burashnikov, C. Antzelevitch, S. Blaser, G. Gross et al., Long QT, syndactyly, joint contractures, stroke and novel CACNA1C mutation: expanding the spectrum of Timothy syndrome, Am. J. Med. Genet. A, vol.158, pp.182-187, 2012.

A. P. Gilmore, A. D. Metcalfe, L. H. Romer, and C. H. Streuli, Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization, J. Cell Biol, vol.149, pp.431-446, 2000.

H. Goepfert, W. J. Dichtel, J. E. Medina, R. D. Lindberg, and M. D. Luna, Perineural invasion in squamous cell skin carcinoma of the head and neck, Am. J. Surg, vol.148, pp.542-547, 1984.

J. G. Goetz, S. Minguet, I. Navarro-lérida, J. J. Lazcano, R. Samaniego et al., Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis, Cell, vol.146, pp.148-163, 2011.

C. K. Goldman, J. Kim, W. L. Wong, V. King, T. Brock et al., Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology, Mol. Biol. Cell, vol.4, pp.121-133, 1993.

V. M. Golubovskaya, Targeting FAK in human cancer: from finding to first clinical trials, Front. Biosci. Landmark Ed, vol.19, pp.687-706, 2014.

V. M. Golubovskaya and W. G. Cance, FAK and p53 protein interactions, Anticancer Agents Med. Chem, vol.11, pp.617-619, 2011.

N. Gomez-ospina, F. Tsuruta, O. Barreto-chang, L. Hu, and R. Dolmetsch, The C terminus of the L-type voltage-gated calcium channel Ca(V)1.2 encodes a transcription factor, Cell, vol.127, pp.591-606, 2006.

Y. Gong, R. Somwar, K. Politi, M. Balak, J. Chmielecki et al., Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas, PLoS Med, vol.4, p.294, 2007.

S. Gopal, L. Veracini, D. Grall, C. Butori, S. Schaub et al., Fibronectin-guided migration of carcinoma collectives, Nat. Commun, vol.8, p.14105, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01783964

M. K. Gordon and R. A. Hahn, Collagens. Cell Tissue Res, vol.339, pp.247-257, 2010.

S. Goswami, E. Sahai, J. B. Wyckoff, M. Cammer, D. Cox et al., Macrophages promote the invasion of breast carcinoma cells via a colonystimulating factor-1/epidermal growth factor paracrine loop, Cancer Res, vol.65, pp.5278-5283, 2005.

J. R. Grandis and D. J. Tweardy, Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer, Cancer Res, vol.53, pp.3579-3584, 1993.

J. R. Grandis, S. D. Drenning, Q. Zeng, S. C. Watkins, M. F. Melhem et al., Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo, Proc. Natl. Acad. Sci. U. S. A, vol.97, pp.4227-4232, 2000.

F. Grange, Épidémiologie des cancers cutanés en France, Dépistage et cancers cutanés, pp.9-20, 2008.

C. Grashoff, B. D. Hoffman, M. D. Brenner, R. Zhou, M. Parsons et al., Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics, Nature, vol.466, pp.263-266, 2010.

C. Grassi, M. D'ascenzo, A. Torsello, G. Martinotti, F. Wolf et al., , 2004.

D. Graus-porta, R. R. Beerli, J. M. Daly, and N. E. Hynes, ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling, EMBO J, vol.16, pp.1647-1655, 1997.

P. C. Gray, V. C. Tibbs, W. A. Catterall, and B. J. Murphy, Identification of a 15-kDa cAMPdependent protein kinase-anchoring protein associated with skeletal muscle L-type calcium channels, J. Biol. Chem, vol.272, pp.6297-6302, 1997.

F. Grinnell, M. Zhu, M. A. Carlson, and J. M. Abrams, Release of mechanical tension triggers apoptosis of human fibroblasts in a model of regressing granulation tissue, Exp. Cell Res, vol.248, p.608, 1999.

K. D. Grugan, C. G. Miller, Y. Yao, C. Z. Michaylira, S. Ohashi et al., Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion, Proc. Natl. Acad. Sci. U. S. A, vol.107, pp.11026-11031, 2010.

A. Gschwind, N. Prenzel, and A. Ullrich, Lysophosphatidic acid-induced squamous cell carcinoma cell proliferation and motility involves epidermal growth factor receptor signal transactivation, Cancer Res, vol.62, pp.6329-6336, 2002.

A. Gschwind, S. Hart, O. M. Fischer, and A. Ullrich, TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells, EMBO J, vol.22, pp.2411-2421, 2003.

A. Gschwind, O. M. Fischer, and A. Ullrich, The discovery of receptor tyrosine kinases: targets for cancer therapy, Nat. Rev. Cancer, vol.4, pp.361-370, 2004.

T. Gudjonsson, L. Rønnov-jessen, R. Villadsen, F. Rank, M. J. Bissell et al., Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition, J. Cell Sci, vol.115, pp.39-50, 2002.

W. J. Gullick, The role of the epidermal growth factor receptor and the c-erbB-2 protein in breast cancer, Int. J. Cancer Suppl. J. Int. Cancer Suppl, vol.5, pp.55-61, 1990.

W. J. Gullick, The Type 1 growth factor receptors and their ligands considered as a complex system, Endocr. Relat. Cancer, vol.8, pp.75-82, 2001.

L. Guo and L. Teng, YAP/TAZ for cancer therapy: Opportunities and challenges (Review), Int. J. Oncol, vol.46, pp.1444-1452, 2015.

C. T. Guy, M. A. Webster, M. Schaller, T. J. Parsons, R. D. Cardiff et al., Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease, Proc. Natl. Acad. Sci. U. S. A, vol.89, pp.10578-10582, 1992.

C. T. Guy, R. D. Cardiff, and W. J. Muller, Activated neu induces rapid tumor progression, J. Biol. Chem, vol.271, pp.7673-7678, 1996.

P. M. Guy, J. V. Platko, L. C. Cantley, R. A. Cerione, and K. L. Carraway, Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity, Proc. Natl. Acad. Sci. U. S. A, vol.91, pp.8132-8136, 1994.

U. Häcker, K. Nybakken, and N. Perrimon, Heparan sulphate proteoglycans: the sweet side of development, Nat. Rev. Mol. Cell Biol, vol.6, pp.530-541, 2005.

G. Halder, J. , and R. L. , Hippo signaling: growth control and beyond, Dev. Camb. Engl, vol.138, pp.9-22, 2011.

G. Halder, S. Dupont, and S. Piccolo, Transduction of mechanical and cytoskeletal cues by YAP and TAZ, Nat. Rev. Mol. Cell Biol, vol.13, pp.591-600, 2012.

K. Hamamura, G. Swarnkar, N. Tanjung, E. Cho, J. Li et al., RhoA-Mediated Signaling in Mechanotransduction of Osteoblasts, Connect. Tissue Res, vol.53, pp.398-406, 2012.

S. L. Hamilton, A. Yatani, K. Brush, A. Schwartz, and A. M. Brown, A comparison between the binding and electrophysiological effects of dihydropyridines on cardiac membranes, Mol. Pharmacol, vol.31, pp.221-231, 1987.

N. E. Hynes and H. A. Lane, ERBB receptors and cancer: the complexity of targeted inhibitors, Nat. Rev. Cancer, vol.5, pp.341-354, 2005.

D. Ili?, B. Kova?i?, K. Johkura, D. D. Schlaepfer, N. Toma?evi? et al., FAK promotes organization of fibronectin matrix and fibrillar adhesions, J. Cell Sci, vol.117, pp.177-187, 2004.

E. Ilijic, J. N. Guzman, and D. J. Surmeier, The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease, Neurobiol. Dis, vol.43, pp.364-371, 2011.

O. Ilina and P. Friedl, Mechanisms of collective cell migration at a glance, J. Cell Sci, vol.122, pp.3203-3208, 2009.

J. R. Infante, D. R. Camidge, L. R. Mileshkin, E. X. Chen, R. J. Hicks et al., Safety, pharmacokinetic, and pharmacodynamic phase I doseescalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.30, pp.1527-1533, 2012.

M. Inukai, S. Toyooka, S. Ito, H. Asano, S. Ichihara et al., , 2006.

M. S. Iordanov, R. J. Choi, O. P. Ryabinina, T. Dinh, R. K. Bright et al., The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Rasextracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor, Mol. Cell. Biol, vol.22, pp.5380-5394, 2002.

Y. Izumi, M. Hirata, H. Hasuwa, R. Iwamoto, T. Umata et al., A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparinbinding EGF-like growth factor, EMBO J, vol.17, pp.7260-7272, 1998.

D. E. Jaalouk and J. Lammerding, Mechanotransduction gone awry, Nat. Rev. Mol. Cell Biol, vol.10, pp.63-73, 2009.

D. Jackman, W. Pao, G. J. Riely, J. A. Engelman, M. G. Kris et al., Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.28, pp.357-360, 2010.

S. P. Jackson and J. Bartek, The DNA-damage response in human biology and disease, Nature, vol.461, pp.1071-1078, 2009.

M. A. Jacobetz, D. S. Chan, A. Neesse, T. E. Bapiro, N. Cook et al., Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer, Gut, vol.62, pp.112-120, 2013.

G. Jacquemet, H. Hamidi, and J. Ivaska, Filopodia in cell adhesion, 3D migration and cancer cell invasion, Curr. Opin. Cell Biol, vol.36, pp.23-31, 2015.

G. Jacquemet, H. Baghirov, M. Georgiadou, H. Sihto, E. Peuhu et al., L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling, Nat. Commun, vol.7, p.13297, 2016.

P. A. Janmey, R. G. Wells, R. K. Assoian, and C. A. Mcculloch, From tissue mechanics to transcription factors, Differentiation, vol.86, pp.112-120, 2013.

R. Jano?tiak, J. Brábek, V. Auernheimer, Z. Tatárová, L. A. Lautscham et al., CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics, Cell. Mol. Life Sci, vol.71, pp.727-744, 2014.

C. Jedeszko, B. C. Victor, I. Podgorski, and B. F. Sloane, Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ, Cancer Res, vol.69, pp.9148-9155, 2009.

C. Jhappan, C. Stahle, R. N. Harkins, N. Fausto, G. H. Smith et al., TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas, Cell, vol.61, pp.1137-1146, 1990.

W. Jia, Z. Zhu, T. Zhang, G. Fan, P. Fan et al., Treatment of malignant ascites with a combination of chemotherapy drugs and intraperitoneal perfusion of verapamil, Cancer Chemother. Pharmacol, vol.71, pp.1585-1590, 2013.

A. Johansson, A. Ansell, F. Jerhammar, M. B. Lindh, R. Grénman et al., Cancer-associated fibroblasts induce matrix metalloproteinase-mediated cetuximab resistance in head and neck squamous cell carcinoma cells, Mol. Cancer Res. MCR, vol.10, pp.1158-1168, 2012.

H. E. Johnson, S. J. King, S. B. Asokan, J. D. Rotty, J. E. Bear et al., F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling, J Cell Biol, vol.208, pp.443-455, 2015.

F. E. Jones and D. F. Stern, Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation, Oncogene, vol.18, pp.3481-3490, 1999.

F. E. Jones, T. Welte, X. Y. Fu, and D. F. Stern, ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation, J. Cell Biol, vol.147, pp.77-88, 1999.

R. N. Jorissen, F. Walker, N. Pouliot, T. P. Garrett, C. W. Ward et al., Epidermal growth factor receptor: mechanisms of activation and signalling, Exp. Cell Res, vol.284, pp.31-53, 2003.

M. Jost, T. M. Huggett, C. Kari, and U. Rodeck, Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway, Mol. Biol. Cell, vol.12, pp.1519-1527, 2001.

J. A. Joyce, Therapeutic targeting of the tumor microenvironment, Cancer Cell, vol.7, pp.513-520, 2005.

J. A. Joyce and J. W. Pollard, Microenvironmental regulation of metastasis, Nat. Rev. Cancer, vol.9, pp.239-252, 2009.

Y. Jung, J. K. Kim, Y. Shiozawa, J. Wang, A. Mishra et al., Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis, Nat. Commun, vol.4, p.1795, 2013.

K. Jurkat-rott, H. Lerche, and F. Lehmann-horn, Skeletal muscle channelopathies, J. Neurol, vol.249, pp.1493-1502, 2002.

A. E. Lacerda, H. S. Kim, P. Ruth, E. Perez-reyes, V. Flockerzi et al., Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel, Nature, vol.352, pp.527-530, 1991.

M. E. Lacouture, Mechanisms of cutaneous toxicities to EGFR inhibitors, Nat. Rev. Cancer, vol.6, pp.803-812, 2006.

D. Lai, K. C. Ho, Y. Hao, Y. , and X. , Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF, Cancer Res, vol.71, pp.2728-2738, 2011.

Y. Lang, D. Gong, F. , and Y. , Calcium channel blocker use and risk of Parkinson's disease: a meta-analysis, Pharmacoepidemiol. Drug Saf, vol.24, pp.559-566, 2015.

R. Lappano and M. Maggiolini, G protein-coupled receptors: novel targets for drug discovery in cancer, Nat. Rev. Drug Discov, vol.10, pp.47-60, 2011.

P. Laurent-puig, A. Cayre, G. Manceau, E. Buc, J. Bachet et al., Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.27, pp.5924-5930, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00618089

V. Lecaudey and D. Gilmour, Organizing moving groups during morphogenesis, Curr. Opin. Cell Biol, vol.18, pp.102-107, 2006.

W. Lederle, B. Hartenstein, A. Meides, H. Kunzelmann, Z. Werb et al., MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma, Carcinogenesis, vol.31, pp.1175-1184, 2010.

J. W. Lee, J. , and R. , Mitogenic signal transduction by integrin-and growth factor receptor-mediated pathways, Mol. Cells, vol.17, pp.188-202, 2004.

D. Lee, K. P. Fong, M. R. King, L. F. Brass, and D. A. Hammer, Differential Dynamics of Platelet Contact and Spreading, Biophys. J, vol.102, pp.472-482, 2012.

K. F. Lee, H. Simon, H. Chen, B. Bates, M. C. Hung et al., Requirement for neuregulin receptor erbB2 in neural and cardiac development, Nature, vol.378, pp.394-398, 1995.

K. Lee, S. S. Lee, S. Kim, B. H. Sohn, H. Lee et al., Significant Association of Oncogene YAP1 with Poor Prognosis and Cetuximab Resistance in Colorectal Cancer Patients, Clin. Cancer Res, vol.21, pp.357-364, 2015.

D. F. Legler, G. Wiedle, F. P. Ross, and B. A. Imhof, Superactivation of integrin alphavbeta3 by low antagonist concentrations, J. Cell Sci, vol.114, pp.1545-1553, 2001.

J. L. Leight, M. A. Wozniak, S. Chen, M. L. Lynch, C. et al., Matrix rigidity regulates a switch between TGF-?1-induced apoptosis and epithelial-mesenchymal transition, Mol. Biol. Cell, vol.23, pp.781-791, 2012.

M. Leu, E. Bellmunt, M. Schwander, I. Fariñas, H. R. Brenner et al., Erbb2 regulates neuromuscular synapse formation and is essential for muscle spindle development, Dev. Camb. Engl, vol.130, pp.2291-2301, 2003.

K. R. Levental, H. Yu, L. Kass, J. N. Lakins, M. Egeblad et al., Matrix crosslinking forces tumor progression by enhancing integrin signaling, Cell, vol.139, pp.891-906, 2009.

G. Levkowitz, H. Waterman, S. A. Ettenberg, M. Katz, A. Y. Tsygankov et al., Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1, Mol. Cell, vol.4, pp.1029-1040, 1999.

J. M. Lewis, T. N. Truong, and M. A. Schwartz, Integrins regulate the apoptotic response to DNA damage through modulation of p53, Proc. Natl. Acad. Sci. U. S. A, vol.99, pp.3627-3632, 2002.

B. Li, M. R. Tadross, and R. W. Tsien, Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression, Science, vol.351, pp.863-867, 2016.

C. I. Li, K. E. Malone, N. S. Weiss, D. M. Boudreau, K. L. Cushing-haugen et al., , vol.98, pp.1504-1513, 2003.

C. I. Li, J. R. Daling, M. C. Tang, K. L. Haugen, P. L. Porter et al., Use of antihypertensive medications and breast cancer risk among women aged 55 to 74 years, JAMA Intern. Med, vol.173, pp.1629-1637, 2013.

H. Li, X. Fan, and J. Houghton, Tumor microenvironment: the role of the tumor stroma in cancer, J. Cell. Biochem, vol.101, pp.805-815, 2007.

J. Li, R. M. Cubbon, L. A. Wilson, M. S. Amer, L. Mckeown et al., Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation, Circ. Res, vol.108, pp.1190-1198, 2011.

J. Li, M. Yang, P. Li, Z. Su, P. Gao et al., Idiopathic pulmonary fibrosis will increase the risk of lung cancer, Chin. Med. J. (Engl.), vol.127, pp.3142-3149, 2014.

S. Li, J. Wang, Y. Wei, Y. Liu, X. Ding et al., Crucial role of TRPC6 in maintaining the stability of HIF-1? in glioma cells under hypoxia, J. Cell Sci, vol.128, pp.3317-3329, 2015.

T. Li, Y. Yang, X. Hua, G. Wang, W. Liu et al., , 2012.

, Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO, Cancer Lett, vol.318, pp.154-161

W. Li, Q. Shi, W. Wang, J. Liu, Q. Li et al., Calcium Channel Blockers and Risk of Breast Cancer: A Meta-Analysis of 17 Observational Studies, PLoS ONE, vol.9, 2014.

Y. Li, B. Guo, Q. Xie, D. Ye, D. Zhang et al., STIM1 Mediates Hypoxia-Driven Hepatocarcinogenesis via Interaction with HIF-1, Cell Rep, vol.12, pp.388-395, 2015.

P. Liao, D. Yu, S. Lu, Z. Tang, M. C. Liang et al., Smooth muscleselective alternatively spliced exon generates functional variation in Cav1.2 calcium channels, J. Biol. Chem, vol.279, pp.50329-50335, 2004.

S. Lim, X. L. Chen, Y. Lim, D. A. Hanson, T. Vo et al., Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation, Mol. Cell, vol.29, pp.9-22, 2008.

R. I. Litvinov, V. Barsegov, A. J. Schissler, A. R. Fisher, J. S. Bennett et al., Dissociation of Bimolecular ?IIb?3-Fibrinogen Complex under a Constant Tensile Force, Biophys. J, vol.100, pp.165-173, 2011.

J. Liu and S. Agarwal, Mechanical signals activate vascular endothelial growth factor receptor-2 to upregulate endothelial cell proliferation during inflammation, J. Immunol. Baltim. Md, vol.185, pp.1215-1221, 1950.

Z. Liu, G. G. Chen, A. C. Vlantis, G. M. Tse, C. K. Shum et al., Calciummediated activation of PI3K and p53 leads to apoptosis in thyroid carcinoma cells, Cell. Mol. Life Sci. CMLS, vol.64, pp.1428-1436, 2007.

Y. Liu-chittenden, B. Huang, J. S. Shim, Q. Chen, S. Lee et al., , 2012.

, Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP, Genes Dev, vol.26, pp.1300-1305

A. Lochter, S. Galosy, J. Muschler, N. Freedman, Z. Werb et al., Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells, J. Cell Biol, vol.139, pp.1861-1872, 1997.

M. Loeffler, J. A. Krüger, A. G. Niethammer, and R. A. Reisfeld, Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake, J. Clin. Invest, vol.116, pp.1955-1962, 2006.

J. D. Loike, L. Cao, S. Budhu, S. Hoffman, and S. C. Silverstein, three-dimensional gels of extracellular matrix proteins, J. Immunol. Baltim. Md, vol.166, pp.7534-7542, 1950.

C. Lu, F. Wu, W. Qiu, and R. Liu, P130Cas substrate domain is intrinsically disordered as characterized by single-molecule force measurements, Biophys. Chem, vol.180, pp.37-43, 2013.

P. Lu, K. Takai, V. M. Weaver, and Z. Werb, Extracellular Matrix Degradation and Remodeling in Development and Disease, Cold Spring Harb. Perspect. Biol, vol.3, 2011.

P. Lu, V. M. Weaver, and Z. Werb, The extracellular matrix: A dynamic niche in cancer progression, J Cell Biol, vol.196, pp.395-406, 2012.

H. A. Lucero and H. M. Kagan, Lysyl oxidase: an oxidative enzyme and effector of cell function, Cell. Mol. Life Sci. CMLS, vol.63, pp.2304-2316, 2006.

N. C. Luetteke, T. H. Qiu, R. L. Peiffer, P. Oliver, O. Smithies et al., TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice, Cell, vol.73, pp.263-278, 1993.

N. C. Luetteke, T. H. Qiu, S. E. Fenton, K. L. Troyer, R. F. Riedel et al., , 1999.

, Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development, Dev. Camb. Engl, vol.126, pp.2739-2750

M. Luo, H. Fan, T. Nagy, H. Wei, C. Wang et al., , 2009.

K. J. Luzzi, I. C. Macdonald, E. E. Schmidt, N. Kerkvliet, V. L. Morris et al.,

, Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases, Am. J. Pathol, vol.153, pp.865-873

T. J. Lynch, D. W. Bell, R. Sordella, S. Gurubhagavatula, R. A. Okimoto et al., Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib, N. Engl. J. Med, vol.350, pp.2129-2139, 2004.

C. D. Madsen and E. Sahai, Cancer dissemination--lessons from leukocytes, Dev. Cell, vol.19, pp.13-26, 2010.

N. Maeda, M. Ishii, K. Nishimura, and K. Kamimura, Functions of chondroitin sulfate and heparan sulfate in the developing brain, Neurochem. Res, vol.36, pp.1228-1240, 2011.

D. Mahalingam, G. Wilding, S. Denmeade, J. Sarantopoulas, D. Cosgrove et al., Mipsagargin, a novel thapsigargin-based PSMAactivated prodrug: results of a first-in-man phase I clinical trial in patients with refractory, advanced or metastatic solid tumours, Br. J. Cancer, vol.114, pp.986-994, 2016.

A. Maity, N. Pore, J. Lee, D. Solomon, and D. M. Rourke, Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia, Cancer Res, vol.60, pp.5879-5886, 2000.

H. P. Makarenkova, M. P. Hoffman, A. Beenken, A. V. Eliseenkova, R. Meech et al., Differential Interactions of FGFs with Heparan Sulfate Control Gradient Formation and Branching Morphogenesis, Sci. Signal, vol.2, p.55, 2009.

I. Malanchi, H. Peinado, D. Kassen, T. Hussenet, D. Metzger et al., Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling, Nature, vol.452, pp.650-653, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00283101

I. Malanchi, A. Santamaria-martínez, E. Susanto, H. Peng, H. Lehr et al., Interactions between cancer stem cells and their niche govern metastatic colonization, Nature, vol.481, pp.85-89, 2011.

R. Malik, P. I. Lelkes, and E. Cukierman, Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer, Trends Biotechnol, vol.33, pp.230-236, 2015.

A. Mammoto, K. M. Connor, T. Mammoto, C. W. Yung, D. Huh et al., A mechanosensitive transcriptional mechanism that controls angiogenesis, Nature, vol.457, pp.1103-1108, 2009.

G. B. Mann, K. J. Fowler, A. Gabriel, E. C. Nice, R. L. Williams et al., Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation, Cell, vol.73, pp.249-261, 1993.

A. Marcantoni, P. Baldelli, J. M. Hernandez-guijo, V. Comunanza, V. Carabelli et al.,

, L-type calcium channels in adrenal chromaffin cells: role in pace-making and secretion, Cell Calcium, vol.42, pp.397-408

A. A. Marino, I. G. Iliev, M. A. Schwalke, E. Gonzalez, K. C. Marler et al., Association between cell membrane potential and breast cancer, Tumour Biol. J. Int. Soc. Oncodevelopmental Biol. Med, vol.15, pp.82-89, 1994.

L. J. Marnett and J. P. Plastaras, Endogenous DNA damage and mutation, Trends Genet. TIG, vol.17, pp.214-221, 2001.

R. Marques, C. G. Peres, C. V. Vaz, I. M. Gomes, M. I. Figueira et al., 5?-Dihydrotestosterone regulates the expression of L-type calcium channels and calcium-binding protein regucalcin in human breast cancer cells with suppression of cell growth, Med. Oncol. Northwood Lond. Engl, vol.32, p.228, 2015.

T. Marsh, K. Pietras, and S. S. Mcallister, Fibroblasts as architects of cancer pathogenesis, Biochim. Biophys. Acta, vol.1832, pp.1070-1078, 2013.

A. Marusyk, V. Almendro, and K. Polyak, Intra-tumour heterogeneity: a looking glass for cancer?, Nat. Rev. Cancer, vol.12, pp.323-334, 2012.

F. Mascia, V. Mariani, G. Girolomoni, and S. Pastore, Blockade of the EGF receptor induces a deranged chemokine expression in keratinocytes leading to enhanced skin inflammation, Am. J. Pathol, vol.163, pp.303-312, 2003.

Y. Matsuo, N. Ochi, H. Sawai, A. Yasuda, H. Takahashi et al., CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer, Int. J. Cancer, vol.124, pp.853-861, 2009.

H. Matsuura, M. Sakaue, K. Subbaramaiah, H. Kamitani, T. E. Eling et al., Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinases, J. Biol. Chem, vol.274, pp.29138-29148, 1999.

P. K. Mattila and P. Lappalainen, Filopodia: molecular architecture and cellular functions, Nat. Rev. Mol. Cell Biol, vol.9, pp.446-454, 2008.

E. Maubec, P. Petrow, I. Scheer-senyarich, P. Duvillard, L. Lacroix et al., Phase II study of cetuximab as first-line single-drug therapy in patients with unresectable squamous cell carcinoma of the skin, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.29, pp.3419-3426, 2011.

M. Maurizi, G. Almadori, G. Ferrandina, M. Distefano, M. E. Romanini et al., Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma, Br. J. Cancer, vol.74, pp.1253-1257, 1996.

A. Mazumdar, L. Adam, D. Boyd, and R. Kumar, Heregulin regulation of urokinase plasminogen activator and its receptor: human breast epithelial cell invasion, Cancer Res, vol.61, pp.400-405, 2001.

D. J. Mcconkey and S. Orrenius, The role of calcium in the regulation of apoptosis, Biochem. Biophys. Res. Commun, vol.239, pp.357-366, 1997.

J. A. Mccubrey, L. S. Steelman, W. H. Chappell, S. L. Abrams, E. W. Wong et al., Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance, Biochim. Biophys. Acta BBA -Mol. Cell Res, vol.1773, pp.1263-1284, 2007.

D. G. Mcneel, J. Eickhoff, F. T. Lee, D. M. King, D. Alberti et al., Phase I trial of a monoclonal antibody specific for alphavbeta3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.11, pp.7851-7860, 2005.

M. B. Meads, R. A. Gatenby, and W. S. Dalton, Environment-mediated drug resistance: a major contributor to minimal residual disease, Nat. Rev. Cancer, vol.9, pp.665-674, 2009.

R. P. Mecham, Overview of extracellular matrix, Curr. Protoc. Cell Biol. Chapter, vol.10, 2001.

L. M. Meenderink, L. M. Ryzhova, D. M. Donato, D. F. Gochberg, I. Kaverina et al., , 2010.

, P130Cas Src-Binding and Substrate Domains Have Distinct Roles in Sustaining Focal Adhesion Disassembly and Promoting Cell Migration, PLOS ONE, vol.5, p.13412

J. Mendelsohn and J. Baselga, The EGF receptor family as targets for cancer therapy, Oncogene, vol.19, pp.6550-6565, 2000.

A. S. Menko, B. M. Bleaken, A. A. Libowitz, L. Zhang, M. A. Stepp et al., A central role for vimentin in regulating repair function during healing of the lens epithelium, Mol. Biol. Cell, vol.25, pp.776-790, 2014.

S. Menon and K. A. Beningo, Cancer cell invasion is enhanced by applied mechanical stimulation, PloS One, vol.6, 2011.

L. M. Merlo, J. W. Pepper, B. J. Reid, and C. C. Maley, Cancer as an evolutionary and ecological process, Nat. Rev. Cancer, vol.6, pp.924-935, 2006.

J. Middelbeek, A. J. Kuipers, L. Henneman, D. Visser, I. Eidhof et al., TRPM7 is required for breast tumor cell metastasis, Cancer Res, vol.72, pp.4250-4261, 2012.

K. S. Midwood and G. Orend, The role of tenascin-C in tissue injury and tumorigenesis, J. Cell Commun. Signal, vol.3, pp.287-310, 2009.

P. J. Miettinen, J. E. Berger, J. Meneses, Y. Phung, R. A. Pedersen et al., , 1995.

, Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor, Nature, vol.376, pp.337-341

L. S. Miller, O. E. Sørensen, P. T. Liu, H. R. Jalian, D. Eshtiaghpour et al., TGF-alpha regulates TLR expression and function on epidermal keratinocytes, J. Immunol. Baltim. Md, vol.174, pp.6137-6143, 1950.

F. Miralles, G. Posern, A. Zaromytidou, and R. Treisman, Actin Dynamics Control SRF Activity by Regulation of Its Coactivator MAL. Cell, vol.113, pp.329-342, 2003.

S. Misale, R. Yaeger, S. Hobor, E. Scala, M. Janakiraman et al., Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer, Nature, vol.486, pp.532-536, 2012.

J. Molnar, K. S. Fong, Q. P. He, K. Hayashi, Y. Kim et al., Structural and functional diversity of lysyl oxidase and the LOX-like proteins, Biochim. Biophys. Acta, vol.1647, pp.220-224, 2003.

C. Montagut, A. Dalmases, B. Bellosillo, M. Crespo, S. Pairet et al., Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer, Nat. Med, vol.18, pp.221-223, 2012.

G. R. Monteith, N. Prevarskaya, and S. J. Roberts-thomson, The calcium-cancer signalling nexus, Nat. Rev. Cancer, vol.17, pp.367-380, 2017.

S. W. Moore, P. Roca-cusachs, and M. P. Sheetz, Stretchy Proteins on Stretchy Substrates: The Important Elements of Integrin-Mediated Rigidity Sensing, vol.19, pp.194-206, 2010.

V. Moulin, S. Larochelle, C. Langlois, I. Thibault, C. A. Lopez-vallé et al., Normal skin wound and hypertrophic scar myofibroblasts have differential responses to apoptotic inductors, J. Cell. Physiol, vol.198, pp.350-358, 2004.

J. K. Mouw, G. Ou, and V. M. Weaver, Extracellular matrix assembly: a multiscale deconstruction, Nat. Rev. Mol. Cell Biol, vol.15, pp.771-785, 2014.

J. K. Mouw, Y. Yui, L. Damiano, R. O. Bainer, J. N. Lakins et al., Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression, Nat. Med, vol.20, pp.360-367, 2014.

M. M. Mueller and N. E. Fusenig, Tumor-Associated Fibroblasts and their Matrix, 2011.

K. Mulgrew, K. Kinneer, X. Yao, B. K. Ward, M. M. Damschroder et al., Direct targeting of alphavbeta3 integrin on tumor cells with a monoclonal antibody, Abegrin. Mol. Cancer Ther, vol.5, pp.3122-3129, 2006.

W. J. Muller, E. Sinn, P. K. Pattengale, R. Wallace, and P. Leder, Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene, Cell, vol.54, pp.105-115, 1988.

L. Munaron, T. Genova, D. Avanzato, S. Antoniotti, F. Pla et al., Targeting calcium channels to block tumor vascularization. Recent Patents Anticancer Drug Discov, vol.8, pp.27-37, 2013.

K. Münger and P. M. Howley, Human papillomavirus immortalization and transformation functions, Virus Res, vol.89, pp.213-228, 2002.

T. Murata, H. Mizushima, I. Chinen, H. Moribe, S. Yagi et al., HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers, Cancer Res, vol.71, pp.6633-6642, 2011.

C. Murdoch, M. Muthana, S. B. Coffelt, and C. E. Lewis, The role of myeloid cells in the promotion of tumour angiogenesis, Nat. Rev. Cancer, vol.8, pp.618-631, 2008.

D. A. Murphy and S. A. Courtneidge, The "ins" and "outs" of podosomes and invadopodia: characteristics, formation and function, Nat. Rev. Mol. Cell Biol, vol.12, pp.413-426, 2011.

A. Nabeshima, Y. Matsumoto, J. Fukushi, K. Iura, T. Matsunobu et al., Tumour-associated macrophages correlate with poor prognosis in myxoid liposarcoma and promote cell motility and invasion via the HB-EGF-EGFR-PI3K/Akt pathways, Br. J. Cancer, vol.112, pp.547-555, 2015.

L. B. Nabors, T. Mikkelsen, S. S. Rosenfeld, F. Hochberg, N. S. Akella et al., Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.25, pp.1651-1657, 2007.

L. B. Nabors, T. Mikkelsen, M. E. Hegi, X. Ye, T. Batchelor et al., A safety run-in and randomized phase 2 study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma (NABTT 0306), Cancer, vol.118, pp.5601-5607, 2012.

S. Naito, S. Kotoh, T. Omoto, Y. Osada, K. Sagiyama et al., Prophylactic intravesical instillation chemotherapy against recurrence after a transurethral resection of superficial bladder cancer: a randomized controlled trial of doxorubicin plus verapamil versus doxorubicin alone, Cancer Chemother. Pharmacol, vol.42, pp.367-372, 1998.

J. Nakai, N. Sekiguchi, T. A. Rando, P. D. Allen, and K. G. Beam, Two regions of the ryanodine receptor involved in coupling with L-type Ca2+ channels, J. Biol. Chem, vol.273, pp.13403-13406, 1998.

Y. Nakashima, K. Yoshinaga, H. Kitao, K. Ando, Y. Kimura et al., Podoplanin is expressed at the invasive front of esophageal squamous cell carcinomas and is involved in collective cell invasion, Cancer Sci, vol.104, pp.1718-1725, 2013.

L. B. Nanney, M. Magid, C. M. Stoscheck, and L. E. King, Comparison of epidermal growth factor binding and receptor distribution in normal human epidermis and epidermal appendages, J. Invest. Dermatol, vol.83, pp.385-393, 1984.

D. Nassar, M. Latil, B. Boeckx, D. Lambrechts, and C. Blanpain, Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma, Nat. Med, vol.21, pp.946-954, 2015.

G. N. Naumov, I. C. Macdonald, P. M. Weinmeister, N. Kerkvliet, K. V. Nadkarni et al., Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy, Cancer Res, vol.62, pp.2162-2168, 2002.

T. R. Neelands, A. P. King, and R. L. Macdonald, Functional expression of L-, N-, P/Q-, and Rtype calcium channels in the human NT2-N cell line, J. Neurophysiol, vol.84, pp.2933-2944, 2000.

P. A. Netti, D. A. Berk, M. A. Swartz, A. J. Grodzinsky, and R. K. Jain, Role of extracellular matrix assembly in interstitial transport in solid tumors, Cancer Res, vol.60, pp.2497-2503, 2000.

K. P. Ng, A. M. Hillmer, C. T. Chuah, W. C. Juan, T. K. Ko et al., A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer, Nat. Med, vol.18, pp.521-528, 2012.

K. Nguyen-ngoc, K. J. Cheung, A. Brenot, E. R. Shamir, R. S. Gray et al., ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium, Proc. Natl. Acad. Sci. U. S. A, vol.109, pp.2595-2604, 2012.

K. M. Nicholson, A. , and N. G. , The protein kinase B/Akt signalling pathway in human malignancy, Cell. Signal, vol.14, pp.381-395, 2002.

R. I. Nicholson, J. M. Gee, and M. E. Harper, EGFR and cancer prognosis, Eur. J. Cancer Oxf, 2001.

. Engl, , vol.4, pp.9-15, 199037.

J. C. Nicholson-fish, M. A. Cousin, and K. J. Smillie, Phosphatidylinositol 3-Kinase Couples Localised Calcium Influx to Activation of Akt in Central Nerve Terminals, Neurochem. Res, vol.41, pp.534-543, 2016.

Z. Ning, D. Chen, A. Liu, P. Fan, Q. Duan et al., Efficacy of chemotherapy combined with targeted arterial infusion of verapamil in patients with advanced gastric cancer, Cell Biochem. Biophys, vol.68, pp.195-200, 2014.

N. Nishida, H. Yano, T. Nishida, T. Kamura, and M. Kojiro, Angiogenesis in Cancer. Vasc. Health Risk Manag, vol.2, pp.213-219, 2006.

S. Noguchi, A. Saito, M. Horie, Y. Mikami, H. I. Suzuki et al., An Integrative Analysis of the Tumorigenic Role of TAZ in Human Non-Small Cell Lung Cancer, Clin. Cancer Res, vol.20, pp.4660-4672, 2014.

N. Normanno, C. Bianco, A. De-luca, and D. S. Salomon, The role of EGF-related peptides in tumor growth, Front. Biosci. J. Virtual Libr, vol.6, pp.685-707, 2001.

N. Normanno, C. Bianco, A. De-luca, M. R. Maiello, and D. S. Salomon, Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment, Endocr. Relat. Cancer, vol.10, pp.1-21, 2003.

N. Normanno, C. Bianco, A. De-luca, M. R. Maiello, and D. S. Salomon, Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment, Endocr. Relat. Cancer, vol.10, pp.1-21, 2003.

N. Normanno, C. Bianco, L. Strizzi, M. Mancino, M. R. Maiello et al., The ErbB receptors and their ligands in cancer: an overview, Curr. Drug Targets, vol.6, pp.243-257, 2005.

N. Normanno, C. Bianco, L. Strizzi, M. Mancino, M. R. Maiello et al., The ErbB receptors and their ligands in cancer: an overview, Curr. Drug Targets, vol.6, pp.243-257, 2005.

N. Normanno, A. De-luca, C. Bianco, L. Strizzi, M. Mancino et al., Epidermal growth factor receptor (EGFR) signaling in cancer, Gene, vol.366, pp.2-16, 2006.

H. Nozawa, C. Chiu, and D. Hanahan, Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis, Proc. Natl. Acad. Sci. U. S. A, vol.103, pp.12493-12498, 2006.

S. Numa, T. Tanabe, H. Takeshima, A. Mikami, T. Niidome et al., Molecular insights into excitation-contraction coupling, Cold Spring Harb. Symp. Quant. Biol, vol.55, pp.1-7, 1990.

F. C. O'connell, M. , and F. , Laminin-rich extracellular matrix association with mammary epithelial cells suppresses Brca1 expression, Cell Death Differ, vol.7, pp.360-367, 2000.

J. T. O'connell, H. Sugimoto, V. G. Cooke, B. A. Macdonald, A. I. Mehta et al., VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization, Proc. Natl. Acad. Sci. U. S. A, vol.108, pp.16002-16007, 2011.

L. E. Odekon, M. B. Frewin, P. Vecchio, T. M. Saba, and P. W. Gudewicz, , 1991.

K. Ohashi, L. V. Sequist, M. E. Arcila, T. Moran, J. Chmielecki et al., Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1, Proc. Natl. Acad. Sci. U. S. A, vol.109, pp.2127-2133, 2012.

D. Öhlund, A. Handly-santana, G. Biffi, E. Elyada, A. S. Almeida et al., Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer, J. Exp. Med, vol.214, pp.579-596, 2017.

Y. Okamoto, T. Ohkubo, T. Ikebe, Y. , and J. , Blockade of TRPM8 activity reduces the invasion potential of oral squamous carcinoma cell lines, Int. J. Oncol, vol.40, pp.1431-1440, 2012.

M. A. Olayioye, R. M. Neve, H. A. Lane, and N. E. Hynes, The ErbB signaling network: receptor heterodimerization in development and cancer, EMBO J, vol.19, pp.3159-3167, 2000.

K. P. Olive, M. A. Jacobetz, C. J. Davidson, A. Gopinathan, D. Mcintyre et al., Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer, Science, vol.324, pp.1457-1461, 2009.

S. F. Oliveria, M. L. Dell'acqua, and W. A. Sather, AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling, Neuron, vol.55, pp.261-275, 2007.

A. F. Olumi, G. D. Grossfeld, S. W. Hayward, P. R. Carroll, T. D. Tlsty et al., , 1999.

, Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium, Cancer Res, vol.59, pp.5002-5011

A. Orimo and R. A. Weinberg, Heterogeneity of stromal fibroblasts in tumors, Cancer Biol. Ther, vol.6, pp.618-619, 2007.

A. Orimo, P. B. Gupta, D. C. Sgroi, F. Arenzana-seisdedos, T. Delaunay et al., Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion, Cell, vol.121, pp.335-348, 2005.

S. Orrenius, B. Zhivotovsky, and P. Nicotera, Regulation of cell death: the calcium-apoptosis link, Nat. Rev. Mol. Cell Biol, vol.4, pp.552-565, 2003.

T. Oskarsson, S. Acharyya, X. H. Zhang, .. Vanharanta, S. Tavazoie et al., Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs, Nat. Med, vol.17, pp.867-874, 2011.

C. H. Österreicher, M. Penz-Österreicher, S. I. Grivennikov, M. Guma, E. K. Koltsova et al., Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver, Proc. Natl. Acad. Sci. U. S. A, vol.108, pp.308-313, 2011.

G. R. Oxnard, V. A. Miller, M. E. Robson, C. G. Azzoli, W. Pao et al., , 2012.

, Screening for germline EGFR T790M mutations through lung cancer genotyping, J. Thorac. Oncol. Off. Publ. Int. Assoc. Study Lung Cancer, vol.7, pp.1049-1052

B. C. Özdemir, T. Pentcheva-hoang, J. L. Carstens, X. Zheng, C. Wu et al., Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival, Cancer Cell, vol.25, pp.719-734, 2014.

J. G. Paez, P. A. Jänne, J. C. Lee, S. Tracy, H. Greulich et al., EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy, Science, vol.304, pp.1497-1500, 2004.

S. Paget, The distribution of secondary growths in cancer of the breast. 1889, Cancer Metastasis Rev, vol.8, pp.98-101, 1989.

D. Pan, The hippo signaling pathway in development and cancer, Dev. Cell, vol.19, pp.491-505, 2010.

K. Pa?ková, D. Rösel, M. Novotný, and J. Brábek, The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells, Cell. Mol. Life Sci, vol.67, pp.63-71, 2010.

W. Pao, V. Miller, M. Zakowski, J. Doherty, K. Politi et al., EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib, Proc. Natl. Acad. Sci. U. S. A, vol.101, pp.13306-13311, 2004.

S. Paquet-fifield, H. Schlüter, A. Li, T. Aitken, P. Gangatirkar et al., A role for pericytes as microenvironmental regulators of human skin tissue regeneration, J. Clin. Invest, vol.119, pp.2795-2806, 2009.

A. Parekh, N. S. Ruppender, K. M. Branch, M. K. Sewell-loftin, J. Lin et al., Sensing and modulation of invadopodia across a wide range of rigidities, Biophys. J, vol.100, pp.573-582, 2011.

C. C. Park, H. Zhang, M. Pallavicini, J. W. Gray, F. Baehner et al., Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo, Cancer Res, vol.66, pp.1526-1535, 2006.

J. Park, D. S. Kim, T. S. Shim, C. M. Lim, Y. Koh et al., Lung cancer in patients with idiopathic pulmonary fibrosis, Eur. Respir. J, vol.17, pp.1216-1219, 2001.

J. H. Park, S. J. Park, M. K. Chung, K. H. Jung, M. R. Choi et al., High expression of large-conductance Ca2+-activated K+ channel in the CD133+ subpopulation of SH-SY5Y neuroblastoma cells, Biochem. Biophys. Res. Commun, vol.396, pp.637-642, 2010.

M. Parri and P. Chiarugi, Rac and Rho GTPases in cancer cell motility control, Cell Commun. Signal. CCS, vol.8, p.23, 2010.

G. Parsonage, A. D. Filer, O. Haworth, G. B. Nash, G. E. Rainger et al.,

, A stromal address code defined by fibroblasts, Trends Immunol, vol.26, pp.150-156

B. Pasternak, H. Svanström, N. M. Nielsen, L. Fugger, M. Melbye et al., Use of calcium channel blockers and Parkinson's disease, Am. J. Epidemiol, vol.175, pp.627-635, 2012.

M. J. Paszek, N. Zahir, K. R. Johnson, J. N. Lakins, G. I. Rozenberg et al., Tensional homeostasis and the malignant phenotype, Cancer Cell, vol.8, pp.241-254, 2005.

M. J. Paszek, C. C. Dufort, O. Rossier, R. Bainer, J. K. Mouw et al., The cancer glycocalyx mechanically primes integrinmediated growth and survival, Nature, vol.511, pp.319-325, 2014.

S. G. Patel and J. P. Shah, TNM staging of cancers of the head and neck: striving for uniformity among diversity, CA. Cancer J. Clin, vol.55, pp.242-258, 2005.

P. K. Pattengale, T. A. Stewart, A. Leder, E. Sinn, W. Muller et al.,

, Animal models of human disease. Pathology and molecular biology of spontaneous neoplasms occurring in transgenic mice carrying and expressing activated cellular oncogenes, Am. J. Pathol, vol.135, pp.39-61

M. W. Pedersen, M. Meltorn, L. Damstrup, and H. S. Poulsen, The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy, Ann. Oncol. Off. J. Eur. Soc. Med. Oncol, vol.12, pp.745-760, 2001.

F. Peglion, F. Llense, E. , and S. , Adherens junction treadmilling during collective migration, Nat. Cell Biol, vol.16, pp.639-651, 2014.

H. Peinado, M. Ale?kovi?, S. Lavotshkin, I. Matei, B. Costa-silva et al., Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET, Nat. Med, vol.18, pp.883-891, 2012.

X. Peng, H. Ueda, H. Zhou, T. Stokol, T. Shen et al.,

, Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice, Cardiovasc. Res, vol.64, pp.421-430

E. Perez-reyes, H. S. Kim, A. E. Lacerda, W. Horne, X. Y. Wei et al., Induction of calcium currents by the expression of the alpha 1-subunit of the dihydropyridine receptor from skeletal muscle, Nature, vol.340, pp.233-236, 1989.

R. Peréz-soler and L. Saltz, Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining?, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.23, pp.5235-5246, 2005.

E. Perozo, Gating prokaryotic mechanosensitive channels, Nat. Rev. Mol. Cell Biol, vol.7, pp.109-119, 2006.

O. W. Petersen, H. L. Nielsen, T. Gudjonsson, R. Villadsen, F. Rank et al., Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma, Am. J. Pathol, vol.162, pp.391-402, 2003.

D. Peus, R. A. Vasa, A. Meves, A. Beyerle, and M. R. Pittelkow, UVB-induced epidermal growth factor receptor phosphorylation is critical for downstream signaling and keratinocyte survival, Photochem. Photobiol, vol.72, pp.135-140, 2000.

M. Pichler, T. N. Cassidy, D. Reimer, H. Haase, R. Kraus et al., Beta subunit heterogeneity in neuronal L-type Ca2+ channels, J. Biol. Chem, vol.272, pp.13877-13882, 1997.

M. W. Pickup, H. Laklai, I. Acerbi, P. Owens, A. E. Gorska et al., Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-?-deficient mouse mammary carcinomas, Cancer Res, vol.73, pp.5336-5346, 2013.

M. W. Pickup, J. K. Mouw, and V. M. Weaver, The extracellular matrix modulates the hallmarks of cancer, EMBO Rep, vol.15, pp.1243-1253, 2014.

M. Piepkorn, Overexpression of amphiregulin, a major autocrine growth factor for cultured human keratinocytes, in hyperproliferative skin diseases, Am. J. Dermatopathol, vol.18, pp.165-171, 1996.

K. Pietras, J. Pahler, G. Bergers, and D. Hanahan, Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting, PLoS Med, vol.5, p.19, 2008.

M. C. Pinto, A. H. Kihara, V. A. Goulart, F. M. Tonelli, K. N. Gomes et al., Calcium signaling and cell proliferation, Cell. Signal, vol.27, pp.2139-2149, 2015.

S. J. Pitt, -. Reilly, B. Donnell, and R. Sitsapesan, Exploring the biophysical evidence that mammalian two-pore channels are NAADP-activated calcium-permeable channels, J. Physiol, vol.594, pp.4171-4179, 2016.

J. W. Pollard, Trophic macrophages in development and disease, Nat. Rev. Immunol, vol.9, pp.259-270, 2009.

J. T. Poterucha, J. N. Johnson, M. Y. Qureshi, P. W. O'leary, P. S. Kamath et al., Magnetic Resonance Elastography: A Novel Technique for the Detection of Hepatic Fibrosis and Hepatocellular Carcinoma After the Fontan Operation, Mayo Clin. Proc, vol.90, pp.882-894, 2015.

N. Prenzel, E. Zwick, H. Daub, M. Leserer, R. Abraham et al., EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF, Nature, vol.402, pp.884-888, 1999.

N. Prevarskaya, R. Skryma, and Y. Shuba, Calcium in tumour metastasis: new roles for known actors, Nat. Rev. Cancer, vol.11, pp.609-618, 2011.

N. Prevarskaya, R. Skryma, and Y. Shuba, Targeting Ca 2+ transport in cancer: close reality or long perspective?, Expert Opin. Ther. Targets, vol.17, pp.225-241, 2013.

N. Prevarskaya, H. Ouadid-ahidouch, R. Skryma, and Y. Shuba, Remodelling of Ca2+ transport in cancer: how it contributes to cancer hallmarks?, Philos. Trans. R. Soc. Lond. B. Biol. Sci, vol.369, 2014.

S. A. Prigent and W. J. Gullick, Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera, EMBO J, vol.13, pp.2831-2841, 1994.

P. P. Provenzano, K. W. Eliceiri, J. M. Campbell, D. R. Inman, J. G. White et al., , 2006.

, Collagen reorganization at the tumor-stromal interface facilitates local invasion, BMC Med, vol.4, p.38

P. P. Provenzano, D. R. Inman, K. W. Eliceiri, S. M. Trier, K. et al., Contact Guidance Mediated Three-Dimensional Cell Migration is Regulated by Rho/ROCK-Dependent Matrix Reorganization, Biophys. J, vol.95, pp.5374-5384, 2008.

P. P. Provenzano, C. Cuevas, A. E. Chang, V. K. Goel, V. Hoff et al., , 2012.

D. F. Quail, J. , and J. A. , Microenvironmental regulation of tumor progression and metastasis, Nat. Med, vol.19, pp.1423-1437, 2013.

M. Quante, S. P. Tu, H. Tomita, T. Gonda, S. S. Wang et al., Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth, Cancer Cell, vol.19, pp.257-272, 2011.

I. S. Ramsey, M. Delling, and D. E. Clapham, An introduction to TRP channels, Annu. Rev. Physiol, vol.68, pp.619-647, 2006.

S. S. Ranade, R. Syeda, and A. Patapoutian, Mechanically Activated Ion Channels, Neuron, vol.87, pp.1162-1179, 2015.

E. Rass, A. Grabarz, P. Bertrand, and B. Lopez, Réparation des cassures double-brin de l'ADN, un mécanisme peut en cacher un autre : la ligature d'extrémités non homologues alternative, Cancer/Radiothérapie, vol.16, pp.1-10, 2012.

R. R. Ratan, F. R. Maxfield, and M. L. Shelanski, Long-lasting and rapid calcium changes during mitosis, J. Cell Biol, vol.107, pp.993-999, 1988.

P. M. Ravdin and G. C. Chamness, The c-erbB-2 proto-oncogene as a prognostic and predictive marker in breast cancer: a paradigm for the development of other macromolecular markers--a review, Gene, vol.159, pp.19-27, 1995.

T. Ravid, C. Sweeney, P. Gee, K. L. Carraway, and T. Goldkorn, Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation, J. Biol. Chem, vol.277, pp.31214-31219, 2002.

M. Razandi, A. Pedram, S. T. Park, and E. R. Levin, Proximal events in signaling by plasma membrane estrogen receptors, J. Biol. Chem, vol.278, pp.2701-2712, 2003.

D. A. Reardon, K. L. Fink, T. Mikkelsen, T. F. Cloughesy, A. O'neill et al., Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.26, pp.5610-5617, 2008.

M. Reffay, M. C. Parrini, O. Cochet-escartin, B. Ladoux, A. Buguin et al., Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells, Nat. Cell Biol, vol.16, pp.217-223, 2014.
URL : https://hal.archives-ouvertes.fr/hal-00992150

A. Reginensi, R. P. Scott, A. Gregorieff, M. Bagherie-lachidan, C. Chung et al., Yap-and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development, PLoS Genet, vol.9, p.1003380, 2013.

N. Reinmuth, W. Liu, S. A. Ahmad, F. Fan, O. Stoeltzing et al., Alphavbeta3 integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in mice, Cancer Res, vol.63, pp.2079-2087, 2003.

N. Reymond, B. B. Água, and A. J. Ridley, Crossing the endothelial barrier during metastasis, Nat. Rev. Cancer, vol.13, pp.858-870, 2013.

L. E. Reynolds, L. Wyder, J. C. Lively, D. Taverna, S. D. Robinson et al., Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins, Nat. Med, vol.8, pp.27-34, 2002.

O. Rho, L. M. Beltrán, I. B. Gimenez-conti, and J. Digiovanni, Altered expression of the epidermal growth factor receptor and transforming growth factor-alpha during multistage skin carcinogenesis in SENCAR mice, Mol. Carcinog, vol.11, pp.19-28, 1994.

S. Ricard-blum and F. Ruggiero, The collagen superfamily: from the extracellular matrix to the cell membrane, Pathol. Biol, vol.53, pp.430-442, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00313933

A. J. Rice, E. Cortes, D. Lachowski, B. C. Cheung, S. A. Karim et al., Matrix stiffness induces epithelial-mesenchymal transition and promotes chemoresistance in pancreatic cancer cells, vol.6, p.352, 2017.

R. C. Rintoul and T. Sethi, The role of extracellular matrix in small-cell lung cancer, Lancet Oncol, vol.2, pp.437-442, 2001.

A. Rio, R. Perez-jimenez, R. Liu, P. Roca-cusachs, J. M. Fernandez et al., , 2009.

, Stretching Single Talin Rod Molecules Activates Vinculin Binding, Science, vol.323, pp.638-641

G. Robert, C. Gaggioli, O. Bailet, C. Chavey, P. Abbe et al., SPARC represses E-cadherin and induces mesenchymal transition during melanoma development, Cancer Res, vol.66, pp.7516-7523, 2006.

W. G. Roberts, E. Ung, P. Whalen, B. Cooper, C. Hulford et al., Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271, Cancer Res, vol.68, pp.1935-1944, 2008.

H. L. Roderick and S. J. Cook, Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival, Nat. Rev. Cancer, vol.8, pp.361-375, 2008.

C. Rodriguez, E. J. Jacobs, A. Deka, A. V. Patel, E. B. Bain et al., Use of blood-pressure-lowering medication and risk of prostate cancer in the Cancer Prevention Study II Nutrition Cohort, Cancer Causes Control CCC, vol.20, pp.671-679, 2009.

Y. Rong, P. Barr, V. C. Yee, and C. W. Distelhorst, Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor, Biochim. Biophys. Acta, vol.1793, pp.971-978, 2009.

Y. Rong, G. Bultynck, A. S. Aromolaran, F. Zhong, J. B. Parys et al., The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor, Proc. Natl. Acad. Sci. U. S. A, vol.106, pp.14397-14402, 2009.

L. Rønnov-jessen, O. W. Petersen, V. E. Koteliansky, and M. J. Bissell, The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells, J. Clin. Invest, vol.95, pp.859-873, 1995.

P. Rørth, Collective guidance of collective cell migration, Trends Cell Biol, vol.17, pp.575-579, 2007.

P. Rørth, Fellow travellers: emergent properties of collective cell migration, EMBO Rep, vol.13, pp.984-991, 2012.

J. Rosenbloom, S. V. Castro, and S. A. Jimenez, Narrative review: fibrotic diseases: cellular and molecular mechanisms and novel therapies, Ann. Intern. Med, vol.152, pp.159-166, 2010.

A. Rosenthal, P. B. Lindquist, T. S. Bringman, D. V. Goeddel, and R. Derynck, Expression in rat fibroblasts of a human transforming growth factor-alpha cDNA results in transformation, Cell, vol.46, pp.301-309, 1986.

A. Rossi, Cetuximab and non-small-cell lung cancer: end of the story?, Lancet Oncol, vol.14, pp.1251-1253, 2013.

D. E. Rowe, R. J. Carroll, and C. L. Day, Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. Implications for treatment modality selection, J. Am. Acad. Dermatol, vol.26, pp.976-990, 1992.

T. Rozario and D. W. Desimone, The extracellular matrix in development and morphogenesis: a dynamic view, Dev. Biol, vol.341, pp.126-140, 2010.

R. Grandis, J. Melhem, M. F. Gooding, W. E. Day, R. Holst et al., Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival, J. Natl. Cancer Inst, vol.90, pp.824-832, 1998.

R. L. Ruff, Skeletal muscle sodium current is reduced in hypokalemic periodic paralysis, Proc. Natl. Acad. Sci. U. S. A, vol.97, pp.9832-9833, 2000.

E. Ruoslahti and J. C. Reed, Anchorage dependence, integrins, and apoptosis, Cell, vol.77, p.477, 1994.

K. S. Russell, D. F. Stern, P. J. Polverini, and J. R. Bender, Neuregulin activation of ErbB receptors in vascular endothelium leads to angiogenesis, Am. J. Physiol, vol.277, pp.2205-2211, 1999.

P. Rybarczyk, M. Gautier, F. Hague, I. Dhennin-duthille, D. Chatelain et al., Transient receptor potential melastatin-related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration, Int. J. Cancer, vol.131, pp.851-861, 2012.

B. Rybinski, J. Franco-barraza, and E. Cukierman, The wound healing, chronic fibrosis, and cancer progression triad, Physiol. Genomics, vol.46, pp.223-244, 2014.

F. Sabeh, I. Ota, K. Holmbeck, H. Birkedal-hansen, P. Soloway et al., Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP, J. Cell Biol, vol.167, pp.769-781, 2004.

F. Sabeh, R. Shimizu-hirota, and S. J. Weiss, Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited, J. Cell Biol, vol.185, pp.11-19, 2009.

E. Sahai and C. J. Marshall, Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis, Nat. Cell Biol, vol.5, pp.711-719, 2003.

U. Sahin, G. Weskamp, K. Kelly, H. Zhou, S. Higashiyama et al., Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands, J. Cell Biol, vol.164, pp.769-779, 2004.

D. S. Salomon, R. Brandt, F. Ciardiello, and N. Normanno, Epidermal growth factor-related peptides and their receptors in human malignancies, Crit. Rev. Oncol. Hematol, vol.19, pp.183-232, 1995.

E. P. Sandgren, N. C. Luetteke, R. D. Palmiter, R. L. Brinster, and D. C. Lee, Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast, Cell, vol.61, pp.1121-1135, 1990.

P. Sandoval, J. A. Jiménez-heffernan, Á. Rynne-vidal, M. L. Pérez-lozano, Á. Gilsanz et al., Carcinoma-associated fibroblasts derive from mesothelial cells via mesothelial-to-mesenchymal transition in peritoneal metastasis, J. Pathol, vol.231, pp.517-531, 2013.

L. Santamaria-kisiel, A. C. Rintala-dempsey, and G. S. Shaw, Calcium-dependent andindependent interactions of the S100 protein family, Biochem. J, vol.396, pp.201-214, 2006.

G. Santoni, S. Caprodossi, V. Farfariello, S. Liberati, A. Gismondi et al., , 2012.

A. M. Santos, J. Jung, N. Aziz, J. L. Kissil, and E. Puré, Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice, J. Clin. Invest, vol.119, pp.3613-3625, 2009.

V. Sanz-moreno, G. Gadea, J. Ahn, H. Paterson, P. Marra et al., Rac activation and inactivation control plasticity of tumor cell movement, Cell, vol.135, pp.510-523, 2008.

I. Sargiannidou, J. Zhou, and G. P. Tuszynski, The role of thrombospondin-1 in tumor progression, Exp. Biol. Med. Maywood NJ, vol.226, pp.726-733, 2001.

A. Sartore-bianchi, F. Di-nicolantonio, M. Nichelatti, F. Molinari, S. De-dosso et al., Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer, PloS One, vol.4, p.7287, 2009.

A. Sartore-bianchi, M. Martini, F. Molinari, S. Veronese, M. Nichelatti et al., PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies, Cancer Res, vol.69, pp.1851-1857, 2009.

Y. Sawada, M. Tamada, B. J. Dubin-thaler, O. Cherniavskaya, R. Sakai et al., Force sensing by mechanical extension of the Src family kinase substrate p130Cas, Cell, vol.127, pp.1015-1026, 2006.

M. Saxena, S. Liu, B. Yang, C. Hajal, R. Changede et al.,

, EGFR and HER2 activate rigidity sensing only on rigid matrices, Nat. Mater. advance online publication

E. A. Schaefer, S. Stohr, M. Meister, A. Aigner, T. Gudermann et al., , 2013.

I. G. Schauer, A. K. Sood, S. Mok, and J. Liu, Cancer-associated fibroblasts and their putative role in potentiating the initiation and development of epithelial ovarian cancer, vol.13, pp.393-405, 2011.

J. Schlessinger, Cell signaling by receptor tyrosine kinases, Cell, vol.103, pp.211-225, 2000.

M. Schober and E. Fuchs, Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-? and integrin/focal adhesion kinase (FAK) signaling, Proc. Natl. Acad. Sci. U. S. A, vol.108, pp.10544-10549, 2011.

J. Schrader, T. T. Gordon-walker, R. L. Aucott, M. Van-deemter, A. Quaas et al., Matrix Stiffness Modulates Proliferation, Chemotherapeutic Response and Dormancy in Hepatocellular Carcinoma Cells, Hepatol. Baltim. Md, vol.53, pp.1192-1205, 2011.

A. B. Schreiber, M. E. Winkler, and R. Derynck, Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor, Science, vol.232, pp.1250-1253, 1986.

E. Schroder, M. Byse, and J. Satin, L-type calcium channel C terminus autoregulates transcription, Circ. Res, vol.104, pp.1373-1381, 2009.

P. C. Schuberth, C. Hagedorn, S. M. Jensen, P. Gulati, M. Van-den-broek et al., Treatment of malignant pleural mesothelioma by fibroblast activation protein-specific re-directed T cells, J. Transl. Med, vol.11, p.187, 2013.

A. C. Schuh, S. J. Keating, F. S. Monteclaro, P. K. Vogt, and M. L. Breitman, Obligatory wounding requirement for tumorigenesis in v-jun transgenic mice, Nature, vol.346, pp.756-760, 1990.

M. A. Schwartz, Integrins and Extracellular Matrix in Mechanotransduction, Cold Spring Harb. Perspect. Biol, vol.2, 2010.

E. C. Schwarz, B. Qu, and M. Hoth, Calcium, cancer and killing: the role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells, Biochim. Biophys. Acta, vol.1833, pp.1603-1611, 2013.

J. E. Schwarzbauer and D. W. Desimone, Fibronectins, Their Fibrillogenesis, and In Vivo Functions, Cold Spring Harb. Perspect. Biol, vol.3, 2011.

R. W. Scott, S. Hooper, D. Crighton, A. Li, I. König et al., LIM kinases are required for invasive path generation by tumor and tumorassociated stromal cells, J. Cell Biol, vol.191, pp.169-185, 2010.

S. Sebens and H. Schafer, The tumor stroma as mediator of drug resistance--a potential target to improve cancer therapy, Curr. Pharm. Biotechnol, vol.13, pp.2259-2272, 2012.