Étude des répercussions de l’ischémie cérébrale sur la plasticité spinale et influence de l’intensité des programmes d’entrainement sur la récupération fonctionnelle

Abstract : Stroke is a major public health issue because associated functional disorders have detrimental impacts on life quality and independence of patients as well as on economic state. This thesis work is focused on 2-research axis concerning cerebral ischemia in rat. The aim of the first axis is to study plasticity at spinal level by investigating the alteration of somatic reflex regulation that could contribute to partially explain functional deficits. Ours results show early fatigue of triceps brachii during an isometric contraction and H-reflex inhibition perturbation post-exercise. We also observed that the disturbance of reflex pathway activity is associated with a decrease of the inhibitory effect induced by muscular metabosensitive afferents that might explain early fatigue and observed functional deficits. The second axis treats about endurance training that is a promising strategy to reduce stroke-induced disorders but remains to improve. In that way, the purpose is to determine which endurance strategy is the most suitable by focusing on exercise intensity. In order to ensure this, the effects of moderate intensity exercise (classically recommended) have been compared to high intensity interval training (HIT) by analysing the functional recovery and cerebral neuroplasticity. Our data show that work intensity, based on lactic threshold, is a critical parameter. Indeed, HIT is more effective for increasing grip strength recovery, aerobic capacity as well as promoting neuroplasticity. The results of these 2 lines of research could be now associated by deepening the HIT effects at cerebral and spinal level that lead to numerous perspectives.
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Caroline Pin-Barre. Étude des répercussions de l’ischémie cérébrale sur la plasticité spinale et influence de l’intensité des programmes d’entrainement sur la récupération fonctionnelle. Médecine humaine et pathologie. Université Côte d'Azur, 2017. Français. ⟨NNT : 2017AZUR4022⟩. ⟨tel-01557699⟩

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