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L’Acide Alpha-Linolénique, précurseur végétal des oméga-3 pour lutter contre les dommages liés à l’accident vasculaire cérébral

Abstract : Stroke is a worldwide major cause of mortality and morbidity without any therapeutic opportunities.While improvements in population health - in the control of major risk factors of stroke - over the pastdecades have contributed to reduced stroke mortality, numerous therapeutics applied acutely after stroke havefailed to improve long-term clinical outcomes. Weirdly, how nutrition may affect stroke damage and recoveryhas not yet been intensely investigated, which is surprising given its great influence as risk factor. Therefore,our lab is investigating an emerging view that is the health potential of a-linolenic acid (ALA is the omega-3contained in plant-derived edible products) in stroke.Our laboratory has previously shown that ALA injections or dietary supplementation reduces strokedamage by direct neuroprotection in rodent models of stroke. As successful translation of putative therapieswill depend on demonstration of efficacy on stroke-induced motor and cognitive deficits, my PhD work hasevaluated the value of ALA supplementation in stroke recovery. I demonstrated that oral and intravenoussupplementation of ALA improved cognitive recovery, which was associated to a better preservation ofhippocampus, a brain structure involved in memory. Looking for mechanistic insights, I also investigated theeffect of ALA supplementation by modification of the daily diet on post-stroke inflammatory response. Wefirst demonstrated a neurotoxic role of the chemokine CCL2 after stroke and identified its reduction, as a keyfactor in brain protection induced by ALA supplementation. In addition, I also contributed to a collaborativestudy deciphering the role of CCL2 in weight loss induced by inflammation of the central nervous system.To conclude, my PhD highlights the importance of ALA supplementation to reduce the consequencesof stroke, targeting post-ischemic pro-inflammatory response and prepare the ground of clinical trial onnutritional interventions that are yet to be evaluated
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Submitted on : Thursday, January 19, 2017 - 12:16:07 PM
Last modification on : Thursday, August 4, 2022 - 4:57:38 PM
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  • HAL Id : tel-01440509, version 1


Miled Bourourou. L’Acide Alpha-Linolénique, précurseur végétal des oméga-3 pour lutter contre les dommages liés à l’accident vasculaire cérébral. Sciences agricoles. Université Côte d'Azur, 2016. Français. ⟨NNT : 2016AZUR4067⟩. ⟨tel-01440509⟩



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