Étude translationnelle de la "rechute" dans l'état de stress post-traumatique : prévention et prédiction du déficit de rappel de l'extinction de la peur conditionnée, chez le rongeur et chez l'humain

Abstract : Consequences of a potentially traumatic event may be different depending on the person affected. While most of the people will recover after the event, others will develop a post-traumatic stress disorder (PTSD). Exposure therapy is one of the best treatments of this disorder and is based on fear extinction training. However, both conditioned fear response and psychotraumatic symptoms may appear again some time after the end of the therapy. Combining fundamental and clinical research, this thesis is aimed at investigating how activity of the ventromedial prefrontal cortex may be related to indicators of prediction and prevention of the return of fear. A consequent objective is to highlight some new possibilities to prevent relapse.Our rat experiments showed that high frequency stimulation of the ventromedial prefrontal cortex reduces the likelihood of return of fear responses. Our experiments with human, with or without post-traumatic stress disorder symptoms, revealed several physiological, cognitive, clinical and socio-demographic predictors.Moreover, we found interpersonal differences that allowed us to characterize qualitative profiles.To sum up, our work demonstrates that the ventromedial prefrontal cortex is involved in multiple ways in the recall of fear extinction. From a clinical perspective, our findings provide suggestions for an innovative development of tools capable to detect individual tendencies to have some deficit in fear extinction recall. This study has, thus, important implications in improving prevention of relapse in post-traumatic stress disorder.
Document type :
Theses
Complete list of metadatas

Cited literature [168 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-00966685
Contributor : Abes Star <>
Submitted on : Thursday, March 27, 2014 - 9:55:53 AM
Last modification on : Friday, September 28, 2018 - 3:14:01 PM
Long-term archiving on : Friday, June 27, 2014 - 11:15:11 AM

File

2013NICE2028.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-00966685, version 1

Collections

Citation

Ophélie Nachon. Étude translationnelle de la "rechute" dans l'état de stress post-traumatique : prévention et prédiction du déficit de rappel de l'extinction de la peur conditionnée, chez le rongeur et chez l'humain. Psychologie. Université Nice Sophia Antipolis, 2013. Français. ⟨NNT : 2013NICE2028⟩. ⟨tel-00966685⟩

Share

Metrics

Record views

1068

Files downloads

5949