J. Cummings, Cognitive and behavioral heterogeneity in Alzheimer's disease: seeking the neurobiological basis, Neurobiol Aging, vol.21, issue.6, pp.845-861, 2000.

T. Ngandu, J. Lehtisalo, A. Solomon, E. Levälahti, S. Ahtiluoto et al., A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial, The Lancet, vol.385, issue.9984, pp.2255-2263, 2015.

A. Rosenberg, F. Mangialasche, T. Ngandu, A. Solomon, and M. Kivipelto, Alzheimer's Disease, and Dementia: From FINGER to World-Wide FINGERS, J Prev Alzheimers Dis, vol.7, issue.1, pp.29-36, 2020.

L. Clare and R. T. Woods, Cognitive training and cognitive rehabilitation for people with early-stage Alzheimer's disease: A review, Neuropsychological Rehabilitation, vol.14, issue.4, pp.385-401, 2004.

M. Butler, E. Mccreedy, V. A. Nelson, P. Desai, E. Ratner et al., Does Cognitive Training Prevent Cognitive Decline?, Ann Intern Med, vol.168, issue.1, p.63, 2017.

, Global Action Plan on the Public Health Response to Dementia, pp.2017-2025, 2017.

S. Ge, Z. Zhu, B. Wu, and E. S. Mcconnell, Technology-based cognitive training and rehabilitation interventions for individuals with mild cognitive impairment: a systematic review, BMC Geriatr, vol.18, issue.1, p.213, 2018.

N. T. Hill, L. Mowszowski, S. L. Naismith, V. L. Chadwick, M. Valenzuela et al., Computerized Cognitive Training in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis, Am J Psychiatry, vol.174, issue.4, pp.329-340, 2017.

J. W. Van-dalen, L. L. Van-wanrooij, M. Van-charante, E. P. Brayne, C. Van-gool et al., Association of Apathy With Risk of Incident Dementia: A Systematic Review and Meta-analysis, JAMA Psychiatry, vol.75, issue.10, pp.1012-1021, 2018.

R. Levy and B. Dubois, Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits, Cereb Cortex, vol.16, issue.7, pp.916-928, 2006.

P. Robert, K. L. Lanctôt, L. Agüera-ortiz, P. Aalten, F. Bremond et al., Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group, Eur Psychiatry, vol.54, pp.71-76, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01850396

M. Husain and J. P. Roiser, Neuroscience of apathy and anhedonia: a transdiagnostic approach, Nat Rev Neurosci, vol.19, issue.8, pp.470-484, 2018.

M. Ruthirakuhan, N. Herrmann, D. Vieira, D. Gallagher, and K. L. Lanctôt, The Roles of Apathy and Depression in Predicting Alzheimer Disease: A Longitudinal Analysis in Older Adults With Mild Cognitive Impairment, Am J Geriatr Psychiatry, vol.27, issue.8, pp.873-882, 2019.

M. Benoit, R. Guerchouche, P. D. Petit, E. Chapoulie, V. Manera et al., Is it possible to use highly realistic virtual reality in the elderly? A feasibility study with image-based rendering, Neuropsychiatr Dis Treat, vol.11, pp.557-563, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01241641

V. Manera, P. Petit, A. Derreumaux, I. Orvieto, M. Romagnoli et al., Kitchen and cooking,' a serious game for mild cognitive impairment and Alzheimer's disease: a pilot study. Front Aging Neurosci, vol.7, p.24, 2015.

V. Manera, S. Abrahams, L. Agüera-ortiz, F. Bremond, R. David et al., Recommendations for the Nonpharmacological Treatment of Apathy in Brain Disorders, Am J Geriatr Psychiatry, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02339088

T. Aalbers, M. A. Baars, O. Rikkert, M. G. Kessels, and R. P. , Puzzling with online games (BAM-COG): reliability, validity, and feasibility of an online self-monitor for cognitive performance in aging adults, J Med Internet Res, vol.15, issue.12, p.270, 2013.

A. König, A. Satt, A. Sorin, R. Hoory, O. Toledo-ronen et al., Automatic speech analysis for the assessment of patients with predementia and Alzheimer's disease, Alzheimers Dement (Amst), vol.1, issue.1, pp.112-124, 2015.

V. Manera, G. Ben-sadoun, T. Aalbers, H. Agopyan, F. Askenazy et al., Recommendations for the Use of Serious Games in Neurodegenerative Disorders: 2016 Delphi Panel, Front Psychol, vol.8, p.1243, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01850326

P. H. Robert, A. König, H. Amieva, S. Andrieu, F. Bremond et al., Recommendations for the use of Serious Games in people with Alzheimer's Disease, related disorders and frailty. Front Aging Neurosci, vol.6, p.54, 2014.

M. Zyda, From visual simulation to virtual reality to games, Computer, vol.38, issue.9, pp.25-32, 2005.

G. Ben-sadoun, V. Manera, J. Alvarez, G. Sacco, and P. Robert, Recommendations for the Design of Serious Games in Neurodegenerative Diseases, Front Aging Neurosci, vol.10, p.13, 2018.

M. F. Folstein, S. E. Folstein, and P. R. Mchugh, Mini-mental state, Journal of Psychiatric Research, vol.12, issue.3, pp.189-198, 1975.

, Diagnostic and Statistical Manual of Mental Disorders: DSM-5, 2013.

A. F. Jorm and P. A. Jacomb, The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): socio-demographic correlates, reliability, validity and some norms, Psychol Med, vol.19, issue.4, pp.1015-1022, 1989.

E. Grober, H. Buschke, H. Crystal, S. Bang, and R. Dresner, Screening for dementia by memory testing, Neurology, vol.38, issue.6, pp.900-903, 1988.

M. Lezak, Neuropsychological Assessment, 1995.

B. Dubois, A. Slachevsky, I. Litvan, and B. Pillon, The FAB: a Frontal Assessment Battery at bedside, Neurology, vol.55, issue.11, pp.1621-1626, 2000.

J. L. Cummings, M. Mega, K. Gray, S. Rosenberg-thompson, D. A. Carusi et al., The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia, Neurology, vol.44, issue.12, pp.2308-2314, 1994.

P. H. Robert, S. Clairet, M. Benoit, J. Koutaich, C. Bertogliati et al., The apathy inventory: assessment of apathy and awareness in Alzheimer's disease, Parkinson's disease and mild cognitive impairment, Int J Geriatr Psychiatry, vol.17, issue.12, pp.1099-1105, 2002.

A. T. Isik, P. Soysal, M. Solmi, and N. Veronese, Bidirectional relationship between caregiver burden and neuropsychiatric symptoms in patients with Alzheimer's disease: A narrative review, Int J Geriatr Psychiatry, vol.34, issue.9, pp.1326-1334, 2019.

P. Sood, S. Kletzel, S. Krishnan, H. Devos, A. Negm et al., Nonimmersive Brain Gaming for Older Adults With Cognitive Impairment: A Scoping Review, Gerontologist, vol.59, issue.6, pp.764-781, 2019.

C. Basak, W. R. Boot, M. W. Voss, and A. F. Kramer, Can training in a real-time strategy video game attenuate cognitive decline in older adults?, Psychol Aging, vol.23, issue.4, pp.765-777, 2008.

K. J. Miller, R. V. Dye, J. Kim, J. L. Jennings, E. O'toole et al., Effect of a computerized brain exercise program on cognitive performance in older adults, Am J Geriatr Psychiatry, vol.21, issue.7, pp.655-663, 2013.

V. Manera, R. Fabre, F. Stella, J. C. Loureiro, L. Agüera-ortiz et al., A survey on the prevalence of apathy in elderly people referred to specialized memory centers, Int J Geriatr Psychiatry, vol.34, issue.10, pp.1369-1377, 2019.

M. Benoit and P. H. Robert, Imaging correlates of apathy and depression in Parkinson's disease, J Neurol Sci, vol.310, issue.1-2, pp.58-60, 2011.

G. Ben-sadoun, G. Sacco, V. Manera, J. Bourgeois, A. König et al., Physical and Cognitive Stimulation Using an Exergame in Subjects with Normal Aging, Mild and Moderate Cognitive Impairment, JAD, vol.53, issue.4, pp.1299-1314, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01785697

V. Booth, R. Harwood, J. E. Hancox, V. Hood-moore, T. Masud et al., Motivation as a mechanism underpinning exercise-based falls prevention programmes for older adults with cognitive impairment: a realist review, BMJ Open, vol.9, issue.6, p.24982, 2019.

G. Y. Lee, C. C. Yip, E. C. Yu, and D. W. Man, Evaluation of a computer-assisted errorless learning-based memory training program for patients with early Alzheimer's disease in Hong Kong: a pilot study, Clin Interv Aging, vol.8, pp.623-633, 2013.

, Essential Facts About the Computer and Video Game Industry, Entertainment Software Association. Entertainment Software Association, 2019.

J. Mishra, J. A. Anguera, and A. Gazzaley, Video Games for Neuro-Cognitive Optimization, Neuron, vol.90, issue.2, pp.214-218, 2016.